Tchem CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta

Protein Summary

Description

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q13554
• A4D2K0
• A4D2K1
• A4D2K2
• A4D2K3
• A4D2K4
• A4D2K5
• A4D2K6
• O95437
• O95438
• O95599
• Q9UGH7
• Q9UGH8
• Q9UGH9
• Q9UNX0
• Q9UNX7
• Q9UP00
• Q9Y5N4
• Q9Y6F4
• CaM kinase II subunit beta

Gene Name

• CAMK2B

Ensembl ID

• ENST00000258682
• ENSP00000258682
• ENSG00000058404
• ENST00000346990
• ENSP00000326518
• ENST00000347193
• ENSP00000326544
• ENST00000350811
• ENSP00000326375
• ENST00000353625
• ENSP00000326427
• ENST00000358707
• ENSP00000351542
• ENST00000395747
• ENSP00000379096
• ENST00000395749
• ENSP00000379098
• ENST00000440254
• ENSP00000397937
• ENST00000457475
• ENSP00000390292

Symbol

• CAM2
• CAMK2
• CAMKB
• CAM2
• CAMK2
• CAMKB
• MRD54

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
biological process	0.94
protein domain	0.92
PubMedID	0.88
disease perturbation	0.83

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camk2 Family / Calcium/calmodulin-dependent Protein Kinase Type Ii Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.41   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 484   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.41   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 484   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0