Property Summary

NCBI Gene PubMed Count 70
PubMed Score 52.66
PubTator Score 51.24

Knowledge Summary

Patent (12,914)

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
psoriasis 6685 1.13284273324049E-83
lung carcinoma 2844 1.87748418600822E-58
oligodendroglioma 2849 1.13855139086158E-14
atypical teratoid / rhabdoid tumor 4369 4.42893466726873E-12
posterior fossa group A ependymoma 1511 4.67615706329908E-12
pilocytic astrocytoma 3086 1.04262375302861E-10
sonic hedgehog group medulloblastoma 1482 3.82020390874257E-10
pediatric high grade glioma 2712 1.46332921855926E-8
medulloblastoma, large-cell 6234 2.0983073287806E-8
osteosarcoma 7933 2.68606098514626E-8
glioblastoma 5572 3.41787666108436E-6
primitive neuroectodermal tumor 3031 4.7157355698194E-5
inflammatory breast cancer 404 3.28043400052019E-4
astrocytic glioma 2241 0.00715973916416523
Disease Target Count Z-score Confidence
Metabolic syndrome X 155 0.0 2.0

Expression

  Differential Expression (14)

Disease log2 FC p
astrocytic glioma -3.100 0.007
posterior fossa group A ependymoma -3.300 0.000
oligodendroglioma -2.500 0.000
psoriasis -2.500 0.000
glioblastoma -4.200 0.000
osteosarcoma 1.474 0.000
sonic hedgehog group medulloblastoma -4.300 0.000
atypical teratoid / rhabdoid tumor -5.900 0.000
medulloblastoma, large-cell -3.800 0.000
primitive neuroectodermal tumor -2.800 0.000
pediatric high grade glioma -4.000 0.000
pilocytic astrocytoma -3.400 0.000
inflammatory breast cancer -1.700 0.000
lung carcinoma 3.500 0.000

Gene

PDB

3BHH  

  Ortholog (5)

Species Source
Macaque OMA EggNOG
Cow OMA Inparanoid
Opossum EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

  TechDev Info (2)

Gary Johnson Kinome profile via MIB/MS Technology
Susumu Tomita Idenitfy substrate

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (25)

PMID Text
25045698 Due to similarity of structure variations, we suggest that these compounds may have an effect on beta-CaMKII and that sengesterone may have a similar efficacy as the control.
22750393 beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells
21884935 Study presents the crystal structure of an autoinhibited full-length human CaMKII holoenzyme, revealing an unexpected compact arrangement of kinase domains docked against a central hub, with the calmodulin-binding sites completely inaccessible.
21871176 Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines.
21610080 Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
21479273 The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19156168 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19058789 Observational study of gene-disease association. (HuGE Navigator)
18302935 These FLIM versions of Camui could be useful for elucidating the function of CaMKII both in vitro and in vivo.
More...

AA Sequence

MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH      1 - 70
SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE     71 - 140
NLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVG    141 - 210
YPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVAS    211 - 280
MMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKAD    281 - 350
GVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVR    351 - 420
RGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPS    421 - 490
PRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKI    491 - 560
CDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQG    561 - 630
RPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ                                      631 - 666
//

Text Mined References (76)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25045698 2014 Possible inhibitor from traditional Chinese medicine for the ? form of calcium-dependent protein kinase type II in the treatment of major depressive disorder.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23989986 2014 A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
22750393 2012 ?-carotene reverses the IL-1?-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells.
22399527 2012 Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
21884935 2011 A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.
21871176 2011 Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.
21610080 2011 Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
21529938 2011 Analysis of CaM-kinase signaling in cells.
More...