PRPF4B
Serine/threonine-protein kinase PRP4 homolog
Protein Summary
Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
- ENST00000337659
- ENSP00000337194
- ENSG00000112739
- ENST00000480058
- ENSP00000433547
- KIAA0536
- PRP4
- PRP4H
- PRP4K
- PR4H
- PRP4
- PRP4H
- PRP4K
- dJ1013A10.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.98 | ||
kinase | 0.98 | ||
hub protein | 0.97 | ||
molecular function | 0.95 | ||
virus perturbation | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.33 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.33 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1