Tchem BIRC2 Baculoviral IAP repeat-containing protein 2

Protein Summary

Description

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q13490
• B4E026
• Q16516
• Q4TTG0

Gene Name

• BIRC2

Ensembl ID

• ENST00000227758
• ENSP00000227758
• ENSG00000110330
• ENST00000530675
• ENSP00000431723
• ENST00000613397
• ENSP00000477613

Symbol

• API1
• MIHB
• RNF48
• API1
• MIHB
• HIAP2
• RNF48
• cIAP1
• Hiap-2
• c-IAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	0.99
chemical	0.95
virus perturbation	0.94
molecular function	0.9

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Baculoviral Iap Repeat-containing Protein 2

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Baculoviral Iap Repeat-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.53   (req: < 5)

Gene RIFs: 152   (req: <= 3)

Antibodies: 447   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.53   (req: >= 5)

Gene RIFs: 152   (req: > 3)

Antibodies: 447   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 525

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0