Tbio TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3

Protein Summary

Description

Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q13488
• O75877
• Q8WVC5
• V-ATPase 116 kDa isoform a3

Gene Name

• TCIRG1

Ensembl ID

• ENST00000265686
• ENSP00000265686
• ENSG00000110719
• ENST00000532635
• ENSP00000434407

Symbol

• ATP6N1C
• ATP6V0A3
• a3
• Stv1
• Vph1
• Atp6i
• OC116
• OPTB1
• TIRC7
• ATP6N1C
• ATP6V0A3
• OC-116kDa

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
biological process	0.94
transcription factor perturbation	0.94
virus perturbation	0.88
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase 116 Kda Subunit A Isoform 3

Protein / Hydrolase / V-type Proton Atpase 116 Kda Subunit A Isoform 3

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase 116 Kda Subunit A Isoform 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.78   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.78   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0