Property Summary

NCBI Gene PubMed Count 33
PubMed Score 72.82
PubTator Score 65.83

Knowledge Summary


No data available


  Disease Sources (6)

Disease Target Count
Prostatic Neoplasms 471
Disease Target Count P-value
lung carcinoma 2844 6.34613792479277E-15
glioblastoma multiforme 347 5.67100012262807E-10
Duchenne muscular dystrophy 602 2.37582042360675E-8
lung cancer 4473 1.1579226281007E-6
ovarian cancer 8492 4.3443959742096E-6
atypical teratoid/rhabdoid tumor 1095 8.01865037376667E-5
adult high grade glioma 2148 2.59402136145597E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 3.65199706978867E-4
interstitial cystitis 2299 4.53453957166423E-4
psoriasis 6685 5.22377837205513E-4
Pick disease 1893 0.00213135104803931
astrocytic glioma 2241 0.00264614330848158
oligodendroglioma 2849 0.00583901638084804
aldosterone-producing adenoma 664 0.0222716632816985
osteosarcoma 7933 0.0282661158760335
ulcerative colitis 2087 0.0291095242836344
Breast cancer 3099 0.030880490660518
subependymal giant cell astrocytoma 2287 0.0370582935428696
Disease Target Count Z-score Confidence
Asthma 349 0.0 2.0
Attention deficit hyperactivity disorder 156 0.0 1.0
Disease Target Count Z-score Confidence
Intellectual disability 573 3.783 1.9
Disease Target Count Z-score Confidence
Botulism 20 4.596 2.3


  Differential Expression (18)

Disease log2 FC p
astrocytic glioma -1.600 0.003
oligodendroglioma -1.200 0.006
psoriasis 1.100 0.001
glioblastoma multiforme -1.600 0.000
osteosarcoma 1.639 0.028
atypical teratoid/rhabdoid tumor 1.500 0.000
Duchenne muscular dystrophy 1.182 0.000
intraductal papillary-mucinous adenoma (... -2.300 0.000
lung cancer 2.800 0.000
Breast cancer 2.800 0.031
interstitial cystitis -2.000 0.000
adult high grade glioma -2.300 0.000
aldosterone-producing adenoma -1.144 0.022
subependymal giant cell astrocytoma -1.274 0.037
lung carcinoma 1.400 0.000
Pick disease -1.600 0.002
ulcerative colitis 1.500 0.029
ovarian cancer -2.200 0.000


Accession Q13454 A8MSM0 D3DSP2 Q14911 Q14912 Q96FW0
Symbols M33


PANTHER Protein Class (2)


4M8G   4M90   4M91   4M92  

  Ortholog (8)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Chicken OMA Inparanoid
S.cerevisiae OMA Inparanoid

Gene RIF (18)

26871953 decreased immunological TUSC3 staining is a factor prognostic of poor survival in pancreatic cancer patients.
26427135 Report frequencies of short tandem repeat markers linked to TUSC3 (MRT7) or NSUN2 (MRT5) genes used for homozygosity mapping of recessive intellectual disability.
25966277 The TUSC3 gene is associated with mental retardation in the Qinba mountain area in China; the sixth exon of the TUSC3 gene may contribute to the risk of developing the disease.
25735931 Loss of TUSC3 alters the molecular response to endoplasmic reticulum stress.
25086101 IGFII and N33 methylation status may be related to gastric carcinogenesis.
24685145 TUSC3 increases glycosylation efficiency for a subset of human glycoproteins by slowing glycoprotein folding.
24435307 TUSC3 loss alters the ER stress response and accelerates prostate cancer growth in vivo
23825019 Homozygous deletion in TUSC3 causes syndromic intellectual disability.
23404293 TUSC3 is a tumor suppressor gene in ovarian cancer.
21739581 A novel nonsense mutation in TUSC3 is responsible for non-syndromic autosomal recessive mental retardation

AA Sequence


Text Mined References (34)

PMID Year Title
26871953 2016 Decreased TUSC3 Promotes Pancreatic Cancer Proliferation, Invasion and Metastasis.
26427135 2015 Frequencies of Six (Five Novel) STR Markers Linked to TUSC3 (MRT7) or NSUN2 (MRT5) Genes Used for Homozygosity Mapping of Recessive Intellectual Disability.
25966277 2015 Association of TUSC3 gene polymorphisms with non-syndromic mental retardation based on nuclear families in the Qinba mountain area of China.
25735931 2015 Tumor suppressor candidate 3 (TUSC3) prevents the epithelial-to-mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells.
25086101 2014 Methylation status of blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population.
24685145 2014 Structural basis of substrate specificity of human oligosaccharyl transferase subunit N33/Tusc3 and its role in regulating protein N-glycosylation.
24483146 2014 Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
24435307 2014 TUSC3 loss alters the ER stress response and accelerates prostate cancer growth in vivo.
23825019 2013 Homozygous deletion in TUSC3 causing syndromic intellectual disability: a new patient.
23594818 2013 Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia.