Property Summary

NCBI Gene PubMed Count 129
PubMed Score 269.35
PubTator Score 87.61

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Colorectal Neoplasms 217
Disease Target Count P-value
osteosarcoma 7933 5.7460426537638E-7
ovarian cancer 8492 3.66947068744645E-6
Multiple myeloma 1328 6.06298420951331E-5
psoriasis 6685 6.38012668302973E-5
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0127150424691417
Waldenstrons macroglobulinemia 765 0.0160907456344522
Polycystic Ovary Syndrome 335 0.0241731212210766
astrocytic glioma 2241 0.0308667981408105
Disease Target Count Z-score Confidence
Cancer 2346 3.513 1.8


  Differential Expression (8)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.443 0.016
Multiple myeloma 2.791 0.000
astrocytic glioma -1.500 0.031
psoriasis -2.600 0.000
osteosarcoma -2.675 0.000
intraductal papillary-mucinous neoplasm ... -1.100 0.013
Polycystic Ovary Syndrome -1.503 0.024
ovarian cancer 3.000 0.000


Accession Q13363 Q4W5N3 Q7Z2Q5 CtBP1
Symbols BARS


PANTHER Protein Class (2)


1MX3   4LCE   4U6Q   4U6S  

  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Fruitfly EggNOG Inparanoid

 GWAS Trait (1)

Gene RIF (75)

26377223 human chorionic gonadotropin stimulated miR-212, which down-regulated OLFM1 and CTBP1 expression in fallopian and endometrial epithelial cells to favor spheroid attachment
26337822 It is a putative target gene of miR-137 in breast neoplasms.
25728771 MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.
25633289 C-terminal-binding protein (CtBP) was found to have an essential role in promoting glutaminolysis by directly repressing the expression of SIRT4.
25483087 CtBP physically interacted with TCF-4, and this interaction was significantly inhibited in the presence of MTOB. The above findings point to a novel role of CtBPs in the promotion of CSC growth and self-renewal
24842953 High CtBP1 expression is associated with Prostate tumor.
24732800 Transactivation of Ctbp was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1 facilitates subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor.
24657618 Crystal structures of human CtBP1 and CtBP2 in complex with 4-Methylthio 2-oxobutyric acid and NAD.
24280726 A transgenic model suggests transcriptional activities of CtBP1 for epithelial mesenchymal interplay and a possibility of a pathogenic role in hair follicle morphogenesis and differentiation.
23940047 dinucleotide binding permits CtBP1 to form an intranuclear homodimer through a Trp(318) switch, creating a nucleation site for multimerization through the C-terminal domain for tetramerization to form an effective repression complex

AA Sequence

PSPGQTVKPEADRDHASDQL                                                      421 - 440

Text Mined References (133)

PMID Year Title
26377223 2015 MicroRNA-212 Regulates the Expression of Olfactomedin 1 and C-Terminal Binding Protein 1 in Human Endometrial Epithelial Cells to Enhance Spheroid Attachment In Vitro.
26337822 2016 miR-137 suppresses the invasion and procedure of EMT of human breast cancer cell line MCF-7 through targeting CtBP1.
25728771 2015 MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.
25633289 2015 CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4.
25483087 2014 Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells.
25416956 2014 A proteome-scale map of the human interactome network.
24842953 2014 Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice.
24732800 2014 CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells.
24722188 2014 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
24657618 2014 Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.