Tchem CRHR2 Corticotropin-releasing factor receptor 2

Protein Summary

Description

G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q13324
• B2R967
• B3SXS6
• B3SXS7
• B3SXS8
• B3SXT0
• F8WA81
• O43461
• Q4QRJ4
• Q99431
• CRF-R-2

Gene Name

• CRHR2

Ensembl ID

• ENST00000341843
• ENSP00000344304
• ENSG00000106113
• ENST00000348438
• ENSP00000340943
• ENST00000471646
• ENSP00000418722
• ENST00000506074
• ENSP00000426498

Symbol

• CRF2R
• CRH2R
• CRF2
• CRFR2
• CRF-RB
• HM-CRF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein)	0.85
protein domain	0.85
biological term	0.67
disease perturbation	0.62
disease	0.59

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class B Secretin Like / Corticotropin-releasing Factor Receptor / Corticotropin-releasing Factor Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.23   (req: < 5)

Gene RIFs: 73   (req: <= 3)

Antibodies: 598   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.23   (req: >= 5)

Gene RIFs: 73   (req: > 3)

Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0