Property Summary

NCBI Gene PubMed Count 66
PubMed Score 123.36
PubTator Score 117.66

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 3.17596933806799E-44
non-small cell lung cancer 2798 1.51976702980344E-13
pancreatic cancer 2300 9.68230006249638E-9
ovarian cancer 8492 1.1185739329114E-6
lung adenocarcinoma 2714 1.68916052158306E-6
invasive ductal carcinoma 2950 3.55992458525385E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 4.98006311083582E-5
intraductal papillary-mucinous neoplasm (IPMN) 3289 2.41174663304884E-4
breast carcinoma 1614 3.12096758432938E-4
lung cancer 4473 7.71252206053583E-4
ductal carcinoma in situ 1745 0.00110762416201812
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00236311934921903
pancreatic carcinoma 567 0.0279429208396572
Disease Target Count Z-score Confidence
Cancer 2346 3.726 1.9



Accession Q13323 Q16582 Q6FH93
Symbols BP4





  Ortholog (4)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid

 GWAS Trait (1)

Gene RIF (42)

25861752 our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM and favors a more aggressive phenotype, due to the molecular change of different pathways
25463603 HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression
25002530 Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.
24637719 BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD.
24554662 Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1.
24527759 Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase signaling.
22873408 A previously undescribed indirect epigenetic regulation of BIK in FA-C lymphoblasts is mediated by DeltaNp73, an isoform of p73 lacking its transactivation domain that activates BIK through a proximal element in its promoter.
22855140 BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients
22388352 Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
22288719 Data indicate that methylation-induced transcriptional silencing of the BIK (bcl2-interacting killer) pro-apoptotic gene may occur in multiple myeloma (MM), which might serve as a predictor of the development of relapsed/refractory MM.

AA Sequence

LLLLALLLPLLSGGLHLLLK                                                      141 - 160

Text Mined References (66)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
25861752 2015 Involvement of multiple cellular pathways in regulating resistance to tamoxifen in BIK-suppressed MCF-7 cells.
25463603 2015 NS5B induces up-regulation of the BH3-only protein, BIK, essential for the hepatitis C virus RNA replication and viral release.
25416956 2014 A proteome-scale map of the human interactome network.
25002530 2014 Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
24637719 2014 BikDDA, a mutant of Bik with longer half-life expression protein, can be a novel therapeutic gene for triple-negative breast cancer.
24554662 2014 Repression of the proapoptotic cellular BIK/NBK gene by Epstein-Barr virus antagonizes transforming growth factor ?1-induced B-cell apoptosis.
24527759 2014 The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G? cell-cycle arrest and not a direct effect on BIK protein stability.
22873408 2012 BIK (NBK) is a mediator of the sensitivity of Fanconi anaemia group C lymphoblastoid cell lines to interstrand DNA cross-linking agents.
22855140 2012 BIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients.