Tchem GPR17 Uracil nucleotide/cysteinyl leukotriene receptor

Protein Summary

Description

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Uniprot Accession IDs

• Q13304
• A8K9L0
• B2R9X0
• Q8N5S7
• Q9UDZ6
• Q9UE21
• UDP/CysLT receptor

Gene Name

• GPR17

Ensembl ID

• ENST00000272644
• ENSP00000272644
• ENSG00000144230
• ENST00000393018
• ENSP00000376741
• ENST00000544369
• ENSP00000442982

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.56
cell type or tissue	0.52
pathway	0.52
tissue sample	0.51
gene perturbation	0.49

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Leukotriene Receptor / Uracil Nucleotide/cysteinyl Leukotriene Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.22   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 362   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.22   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3