Property Summary

NCBI Gene PubMed Count 40
PubMed Score 53.66
PubTator Score 46.80

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count
Microvillus inclusion disease 2
Disease Target Count P-value
malignant mesothelioma 3163 8.31140561449452E-8
osteosarcoma 7933 2.95404283301787E-7
ulcerative colitis 2087 1.55452232553078E-6
medulloblastoma, large-cell 6234 3.75788560310746E-6
Pick disease 1893 2.8304167770807E-5
group 3 medulloblastoma 2254 2.87783754623039E-5
invasive ductal carcinoma 2950 1.11423830909196E-4
ductal carcinoma in situ 1745 4.8145064103666E-4
psoriasis 6685 6.28072957623772E-4
pituitary cancer 1972 0.00238890040042623
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00958961124149678
spina bifida 1064 0.0217868459461746
axial spondyloarthropathy 28 0.046126830192839
Disease Target Count Z-score Confidence
Tetanus 66 4.034 2.0


  Differential Expression (13)

Disease log2 FC p
malignant mesothelioma 1.900 0.000
psoriasis 1.200 0.001
osteosarcoma -2.533 0.000
medulloblastoma, large-cell 2.400 0.000
intraductal papillary-mucinous neoplasm ... 1.100 0.010
group 3 medulloblastoma 2.500 0.000
spina bifida -1.572 0.022
Pick disease -1.100 0.000
ductal carcinoma in situ 1.300 0.000
invasive ductal carcinoma 1.900 0.000
ulcerative colitis -1.700 0.000
pituitary cancer 1.700 0.002
axial spondyloarthropathy 1.100 0.046


Accession Q13277 B4DME0 O43750 O43751 Q15360
Symbols STX3A


  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (17)

26553929 GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3.
25673875 Rab11a-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment
25630102 The results showed that there was reduction in aggregation propensity of syntaxin-3 with point mutation at Val286.
25583387 hcmv-miR-US33-5p-mediated inhibition of HCMV DNA synthesis and of viral replication are specifically mediated by down-regulation of STX3 expression.
25548252 the secretion of IL-1alpha, IL-1beta, IL-12b, and CCL4 occurs during gelatinase degranulation, a process controlled by STX3.
25358429 we report for the first time a missense mutation of a novel lens specific gene STX3 in a phenotype associating autosomal recessive congenital cataract and intellectual disability.
24726755 loss of STX3 function causes variant microvillus inclusion disease
24171760 syntaxin3 has a latent prosurvival function and is involved in maintenance of homeostasis in epidermal keratinocytes
23132338 In insulin secretion, SYN-3 plays a role in the mediation of newcomer SG exocytosis and SG-SG fusion that contributes to biphasic GSIS.
21981832 STX-3 and SNAP-23 are crucial for the release of all chemokines in mature human mast cells

AA Sequence

IIGLSVGLN                                                                 281 - 289

Text Mined References (43)

PMID Year Title
26553929 2015 Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25673875 2015 Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes.
25630102 2014 Effect of mutation on aggregation propensity in homology model structures of syntaxin-3 from Homo sapiens.
25583387 2015 Human cytomegalovirus miR-US33-5p inhibits viral DNA synthesis and viral replication by down-regulating expression of the host Syntaxin3.
25548252 2015 An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1?, IL-1?, IL-12b, and CCL4 from differentiated HL-60 cells.
25416956 2014 A proteome-scale map of the human interactome network.
25358429 2015 Autosomal recessive congenital cataract, intellectual disability phenotype linked to STX3 in a consanguineous Tunisian family.
24726755 2014 Loss of syntaxin 3 causes variant microvillus inclusion disease.
24171760 2013 Effluent syntaxin3 from dying cells affords protection against apoptosis in epidermal keratinocytes.