Property Summary

NCBI Gene PubMed Count 50
PubMed Score 87.67
PubTator Score 57.96

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Endometrial Neoplasms 50
Disease Target Count P-value
lung cancer 4473 5.20595257257003E-5
adult high grade glioma 2148 1.19763439393196E-4
glioblastoma 5572 9.41580654752725E-4
interstitial cystitis 2299 0.0025781826533579
esophageal adenocarcinoma 737 0.0190553920760902
medulloblastoma, large-cell 6234 0.024768366858791
Disease Target Count Z-score Confidence
Brachial plexus lesion 4 3.606 1.8
Cancer 2346 3.042 1.5

Expression

  Differential Expression (6)

Disease log2 FC p
esophageal adenocarcinoma -1.200 0.019
glioblastoma -1.100 0.001
medulloblastoma, large-cell 1.200 0.025
lung cancer 2.200 0.000
interstitial cystitis -1.200 0.003
adult high grade glioma -1.200 0.000

Synonym

Accession Q13275 C9JQ85 Q13274 Q13372 Q15704 Q6GTR4
Symbols SEMA4
SEMAK
SEMA-IV

Gene

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Anole lizard OMA Inparanoid

 GO Component (1)

Gene RIF (35)

PMID Text
26784191 A new SEMA3F transcript is expressed in all breast cell lines and breast cancer biopsies, and is translated into a new semaphorin 3F isoform.
26722466 SEMA3F was downregulated in colorectal cancer tissues as compared to matched adjacent non-tumor tissues
26156437 SEMA3F-NRP2 interactions inhibit intracellular PI-3K activity, mTORC2-dependent signaling, RhoA activity and cytoskeletal stress fiber formation.
26086095 Infantile hemangioma-derived stem cells and endothelial cells are inhibited by SEMA3E and SEMA3F.
25952650 SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer progression, hence serving as a prognostic biomarker and an attractive target for therapeutic intervention to halt metastasis.
25866254 SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis.
25529012 Our findings demonstrate the ability of SEMA3F to inhibit the stemness of human CRC cells by suppressing Rac1 activation, which suggests a novel therapeutic approach for colorectal cancer
25068647 Data indicate that semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) are expressed in the thymus.
24079887 Data suggest that SEMA3F C-terminal domain exhibits high-affinity binding of neuropilin-1 (NRP1; thus inhibiting binding of vascular endothelial growth factor A to NRP1); this interaction may be involved in anti-angiogenic activity of SEMA3F.
23603393 A functional role for Semaphorin 3F in the outer retina where it acts as a vasorepulsive cue to maintain physiologic avascularity.
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AA Sequence

MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMY      1 - 70
VGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNP     71 - 140
MCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTA    141 - 210
SALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFR    211 - 280
ERSAEAPQSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDV    281 - 350
RNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS    351 - 420
MKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTV    421 - 490
QKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCL    491 - 560
ARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRS    561 - 630
PQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRD    631 - 700
AVHAALFPPLSMSAPPPPGAGPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQ    701 - 770
DQKKPRNRRHHPPDT                                                           771 - 785
//

Text Mined References (51)

PMID Year Title
26784191 2016 Alternative Splicing in Adhesion- and Motility-Related Genes in Breast Cancer.
26722466 2015 Semaphorin-3F functions as a tumor suppressor in colorectal cancer due to regulation by DNA methylation.
26156437 2015 Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.
26086095 2015 Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins.
25952650 2015 Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.
25866254 2015 SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.
25529012 2015 Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1.
25068647 2014 Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors.
24079887 2013 Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F.
23603393 2013 Semaphorin 3F forms an anti-angiogenic barrier in outer retina.
More...