Property Summary

NCBI Gene PubMed Count 50
Grant Count 52
R01 Count 11
Funding $4,627,770.7
PubMed Score 87.67
PubTator Score 57.96

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (6)

Disease log2 FC p
esophageal adenocarcinoma -1.200 0.019
glioblastoma -1.100 0.001
medulloblastoma, large-cell 1.200 0.025
lung cancer 2.200 0.000
interstitial cystitis -1.200 0.003
adult high grade glioma -1.200 0.000

 GO Component (1)

Gene RIF (35)

PMID Text
26784191 A new SEMA3F transcript is expressed in all breast cell lines and breast cancer biopsies, and is translated into a new semaphorin 3F isoform.
26722466 SEMA3F was downregulated in colorectal cancer tissues as compared to matched adjacent non-tumor tissues
26156437 SEMA3F-NRP2 interactions inhibit intracellular PI-3K activity, mTORC2-dependent signaling, RhoA activity and cytoskeletal stress fiber formation.
26086095 Infantile hemangioma-derived stem cells and endothelial cells are inhibited by SEMA3E and SEMA3F.
25952650 SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer progression, hence serving as a prognostic biomarker and an attractive target for therapeutic intervention to halt metastasis.
25866254 SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis.
25529012 Our findings demonstrate the ability of SEMA3F to inhibit the stemness of human CRC cells by suppressing Rac1 activation, which suggests a novel therapeutic approach for colorectal cancer
25068647 Data indicate that semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) are expressed in the thymus.
24079887 Data suggest that SEMA3F C-terminal domain exhibits high-affinity binding of neuropilin-1 (NRP1; thus inhibiting binding of vascular endothelial growth factor A to NRP1); this interaction may be involved in anti-angiogenic activity of SEMA3F.
23603393 A functional role for Semaphorin 3F in the outer retina where it acts as a vasorepulsive cue to maintain physiologic avascularity.
More...

AA Sequence

MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMY      1 - 70
VGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNP     71 - 140
MCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTA    141 - 210
SALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFR    211 - 280
ERSAEAPQSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDV    281 - 350
RNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS    351 - 420
MKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTV    421 - 490
QKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCL    491 - 560
ARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRS    561 - 630
PQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRD    631 - 700
AVHAALFPPLSMSAPPPPGAGPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQ    701 - 770
DQKKPRNRRHHPPDT                                                           771 - 785
//

Text Mined References (51)

PMID Year Title
26784191 2016 Alternative Splicing in Adhesion- and Motility-Related Genes in Breast Cancer.
26722466 2015 Semaphorin-3F functions as a tumor suppressor in colorectal cancer due to regulation by DNA methylation.
26156437 2015 Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.
26086095 2015 Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins.
25952650 2015 Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.
25866254 2015 SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.
25529012 2015 Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1.
25068647 2014 Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors.
24079887 2013 Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F.
23603393 2013 Semaphorin 3F forms an anti-angiogenic barrier in outer retina.
More...