Property Summary

NCBI Gene PubMed Count 86
PubMed Score 11.81
PubTator Score 88.63

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
ulcerative colitis 2087 1.31182026328343E-8
malignant mesothelioma 3163 5.12384323846288E-8
osteosarcoma 7933 1.81214844702352E-7
interstitial cystitis 2299 1.77122176364452E-5
lung cancer 4473 1.27560352175738E-4
cutaneous lupus erythematosus 1056 9.61709273409196E-4


  Differential Expression (6)

Disease log2 FC p
malignant mesothelioma 2.700 0.000
cutaneous lupus erythematosus 1.200 0.001
osteosarcoma -1.805 0.000
lung cancer -1.700 0.000
interstitial cystitis 1.800 0.000
ulcerative colitis 1.200 0.000



4GS7   2Z3Q   2Z3R   2ERS  

  Ortholog (5)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid

Gene RIF (72)

26719339 The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for antigen delivery.
26675759 Report improved antitumoral NK-cell activity in DC-based vaccine strategies through the use of IL-15/IL-15Ralpha mRNA-engineered designer DC.
25964490 IRF-1 promotes LTx I/R injury via hepatocyte IL-15/IL-15Ralpha production and suggest that targeting IRF-1 and IL-15/IL-15Ralpha may be effective in reducing I/R injury associated with LTx.
25879761 Report Il15Ralpha levels in synovial fluid from rheumatoid arthritis patients.
25412359 NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Ralpha expression
25387549 significant association of rs2228059 with ossification of the posterior longitudinal ligament of the spine in Chinese Han population
24980552 Coexpression of IL15RA and IL15 was also sufficient to activate peripheral blood mononuclear cells.
24912180 Data suggest that the Interleukin (IL)-15 and interleukin 15 receptor alpha (IL-15.IL-15Ralpha) complex cleaved from presenting cells allows responding cells to internalize, store and use IL-15.IL-15Ralpha complex for their own proliferation and survival.
24696261 This present study demonstrated that IL15RA rs2228059 A > C polymorphism might modify Gastric cardiac adenocarcinoma susceptibility
24603895 Circulating levels of IL-15 and IL-15Ralpha seem to reflect visceral distribution of adipose tissue; epicardial fat may be a potential source of both IL-15 and IL-15Ralpha.

AA Sequence


Text Mined References (89)

PMID Year Title
26719339 2016 Configuration-dependent Presentation of Multivalent IL-15:IL-15R? Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity.
26675759 2015 Transpresentation of interleukin-15 by IL-15/IL-15R? mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity.
25964490 2015 IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15R? production.
25879761 2015 Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from rheumatoid arthritis patients.
25412359 2014 NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15R? expression.
25387549 2014 Association between single nucleotide polymorphism of IL15RA gene with susceptibility to ossification of the posterior longitudinal ligament of the spine.
24980552 2014 IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.
24912180 2014 IL-15.IL-15R? complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells.
24696261 2014 Interleukin 15 receptor alpha rs2228059 A > C polymorphism decreased risk of gastric cardiac adenocarcinoma in a Chinese population.
24603895 2014 Interleukin-15 and soluble interleukin-15 receptor ? in coronary artery disease patients: association with epicardial fat and indices of adipose tissue distribution.