Property Summary

NCBI Gene PubMed Count 161
PubMed Score 26.92
PubTator Score 285.24

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 2.26613908778544E-36
breast carcinoma 1614 2.5069725581553E-31
psoriasis 6685 4.43784571224598E-14
adrenocortical carcinoma 1427 5.50563869159538E-9
glioblastoma 5572 8.17994854112298E-9
medulloblastoma, large-cell 6234 9.49150452637952E-8
atypical teratoid/rhabdoid tumor 1095 4.1115253354861E-7
sonic hedgehog group medulloblastoma 1482 5.14584659514223E-7
colon cancer 1475 6.50285845309343E-7
nasopharyngeal carcinoma 1056 6.6292360321232E-7
pituitary cancer 1972 1.52663653129554E-6
pediatric high grade glioma 2712 1.78640612218988E-6
lung cancer 4473 2.34293108461368E-6
pancreatic cancer 2300 5.33330453232932E-6
primitive neuroectodermal tumor 3031 2.38382181141874E-5
posterior fossa group A ependymoma 1511 2.93050897619595E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 1.38541570997066E-4
invasive ductal carcinoma 2950 3.04728688160067E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 5.39660756558852E-4
lung adenocarcinoma 2714 6.7253288884156E-4
ovarian cancer 8492 0.00120149264153254
Atopic dermatitis 944 0.00169888590161243
ductal carcinoma in situ 1745 0.00203910251879747
active Crohn's disease 918 0.00525827836970197
primary Sjogren syndrome 789 0.00692220618970233
Endometriosis 535 0.0205609815587005
Breast cancer 3099 0.0307912953732674
Disease Target Count Z-score Confidence
Cancer 2346 3.097 1.5



Accession Q13257 Q53F56 Q548X9 Q6IRW7 Q8IZX3 HsMAD2
Symbols MAD2



1GO4   5LCW   2QYF   1DUJ   1KLQ   1S2H   2V64   2VFX   3GMH  

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (110)

26544187 p31comet-induced cell death is mediated by interactions with Mad2
26489879 Studied the folding/unfolding process of the open and closed conformers of human Mad2.
26305957 Data indicate the structure of the intermediate conformer of the multistate checkpoint protein mitotic arrest deficient 2 (Mad2) protein.
26287798 MAD2L1 and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.
26183163 MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer
25898113 We also show that replication perturbations result in relocalization of MAD1/MAD2 in human cells, suggesting that the role of SAC in DNA repair is conserved.
25637637 CDC20, MAD2 and Aurora-B protein expression are associated with chromosomal abnormalities and poor prognosis in patients with myelodysplastic syndromes.
25503128 MAD2 may be involved in oral carcinogenesis and may represent an important prognostic factor associated with a more malignant phenotype of oral squamous cell carcinoma.
25483095 In conclusion, the results presented here suggest that Mad2 and BubR1 could be used as prognostic markers of tumor progression and new pharmacological targets in the treatment for gastric cancer .
25422469 the interaction of FAT10 with MAD2 is a key mechanism underlying the promalignant property of FAT10

AA Sequence


Text Mined References (170)

PMID Year Title
26544187 2015 p31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26489879 2016 Stable folding intermediates prevent fast interconversion between the closed and open states of Mad2 through its denatured state.
26305957 2015 Structure of an intermediate conformer of the spindle checkpoint protein Mad2.
26287798 2015 Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis.
26183163 2015 MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer.
25898113 2015 DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.
25637637 2015 Proteins of the mitotic checkpoint and spindle are related to chromosomal instability and unfavourable prognosis in patients with myelodysplastic syndrome.
25503128 2014 MAD2 expression in oral squamous cell carcinoma and its relationship to tumor grade and proliferation.
25483095 2014 Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells.