Tchem GRM1 Metabotropic glutamate receptor 1

Protein Summary

Description

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q13255
• B9EG79
• F8W805
• Q13256
• Q14757
• Q14758
• Q5VTF7
• Q5VTF8
• Q9NU10
• Q9UGS9
• Q9UGT0
• mGluR1

Gene Name

• GRM1

Ensembl ID

• ENST00000282753
• ENSP00000282753
• ENSG00000152822
• ENST00000355289
• ENSP00000347437
• ENST00000361719
• ENSP00000354896
• ENST00000492807
• ENSP00000424095
• ENST00000507907
• ENSP00000425599

Symbol

• GPRC1A
• MGLUR1
• MGLU1
• SCA44
• GPRC1A
• MGLUR1
• SCAR13
• PPP1R85

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1
protein domain	0.99
trait	0.93
hub protein	0.79
biological process	0.78

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Metabotropic Glutamate Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class C Metabotropic Glutamate/pheromone / Metabotropic Glutamate Receptor / Metabotropic Glutamate Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1046.8   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 664   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1046.8   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 664   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 380

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0