Property Summary

NCBI Gene PubMed Count 225
PubMed Score 1954.56
PubTator Score 690.80

Knowledge Summary

Patent (26,145)

TINX Plot

  Disease (8)

Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Alzheimer's disease 644 4.636 2.3
Disease Target Count Z-score Confidence
Intellectual disability 573 3.197 1.6

Expression

  Differential Expression (13)

Disease log2 FC p
astrocytic glioma -2.500 1.2e-03
ependymoma -2.800 1.2e-03
oligodendroglioma -2.300 3.0e-03
glioblastoma -3.300 8.8e-06
osteosarcoma -1.067 3.3e-04
medulloblastoma -2.900 7.7e-06
atypical teratoid / rhabdoid tumor -3.200 3.2e-07
medulloblastoma, large-cell -2.800 3.1e-03
primitive neuroectodermal tumor -2.600 1.7e-03
adult high grade glioma -2.800 2.3e-04
pilocytic astrocytoma -1.700 5.4e-04
non primary Sjogren syndrome sicca -1.100 2.9e-02
psoriasis -1.600 7.1e-20

Gene RIF (217)

PMID Text
26912815 GluN2B appears to exhibit allosteric regulation/inhibition by two distinct classes of antagonists; data from in silico docking suggest that GluN2B-selective antagonists broadly divide into two distinct classes according to binding pose.
26884337 both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
26819771 GRIN2B (rs7301328) was significantly associated with disruptive behavior in adolescents.
26627941 GRIN2B polymorphisms do not influence Parkinson disease age of onset in the US Caucasian population.
26584860 Knockdown of PKD1 did not affect NMDAR internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR-mediated synaptic functions.
26321256 GRIN2B encodes the NR2 subunit of NMDA receptors, which are a class of ionotropic glutamate receptors involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission.
26252487 ligand binding to cell surface GD2 induces rapid and transient activation of Src-family kinases, followed by Src-dependent phosphorylation of NMDA-receptor NR2B subunits selectively.
26081945 GFAP peaks early during haemorrhagic brain lesions (at significantly higher levels), and late in ischaemic events, whereas antibodies against NR2 RNMDA have significantly higher levels during ischemic stroke at all time-points.
26020650 Study provides evidence of an association between GRIN2B polymorphisms and Schizophrenia susceptibility and symptoms in the Han Chinese population.
25896831 Polymorphisms in DRD1, DRD2 and GRIN2B confer increased risk of impulse control problems among PD patients.
25893192 BDNF, APOE, and HSP70-1 genes, but not GRIN2B, might be associated with a risk of POAG occurrence in the Polish population
25760043 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
25693086 421C/A polymorphism not associated with risk of occurrence of primary open-angle glaucoma
25660313 did not find significant pooled Odds Ratios for any of the six genes, under different models and stratifying for ethnicity.
25656819 common variants and related haplotypes of GRIN2B are associated with autism risk.
25613138 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
25585032 The GluN2B-containing NMDA receptors (GluN2B/GluN1) were increased in schizophrenia in hippocampal CA3 tissue, but not in hippocampal CA1 tissue.
25486778 Association of GRIN2B gene polymorphisms with paranoid schizophrenia and response to common neuroleptics in Russians and Tatars from Bashkortostan Republic.
25467983 Genetic polymorphisms and isogenic deletions of loop-bound sequences conferred liability for cognitive performance and decreased GRIN2B expression.
25431428 results suggest that NMDA-R autoantibodies are unlikely to account for a large proportion of treatment-refractory psychosis.
25426763 This study provides further evidence in support of GRIN2B contributing toward Developmental Dyslexia and deficits in Developmental Dyslexia
25292222 first evidence of GluN2 protein abnormalities in the hippocampus in schizophrenia, highlighting the hippocampal lateralisation in this disorder. Only left hippocampus deficient in GluN2B.
25261450 Study found GluN receptor subunit-specific changes in mixed subcortical ischemic vascular dementia(SIVD)/Alzheimer's disease(AD) (decreased GluN1) and SIVD (increased GluN2A and 2B), likely reflecting interaction of ischemic neurovascular and AD processes
25052836 BDNF/TrkB signaling plays an important role in the NRG1-stimulated NR2B regulation.
24925192 The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2B.
24739951 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
24503147 GRIN2B is likely to be related to neuro-developmental anomalies.
24491052 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
24490167 we hypothesized that GRIN2B risk allele is associated with reductions of brain white matter integrity in the frontal, parietal, temporal, and occipital regions and cingulate gyrus in bipolar disorder
24292895 Results advocate that genetic variability in GRIN2B gene, involved in synaptic functioning, might provide valuable insights into disease pathogenesis, continuing to attract significant attention in biomedical research on its genetic and functional role
24272827 GRIN2B gain-of-function gene mutations causing West syndrome are identified in two patients with severe developmental delay and focal epilepsy.
24156266 Results show that the expression and distribution of NMDA receptors subunits GluN1, GluN2A and GluN2B - together with that of postsynaptic protein PSD-95 - are modified in Alzheimer's disease compared to normal aging
24114429 Results suggest that four potentially functional polymorphisms of GRIN2B confer susceptibility to treatment-resistant depression (TRD), and are genetic predictors of TRD in major depressive disorder patients
24086760 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
23918416 We report here on the first cases of GRIN2B deletion, enlarging the spectrum of GRIN2B abnormalities. Our findings confirm the involvement of this gene in neurodevelopmental disorders.
23855403 The results demonstrate the contribution of Grin2b via DISC1 on the risk of Schizophrenia
23840674 Association of multiple sclerosis disease severity and allelic variants of the NR1 and NR2B glutamate receptor genes.
23718928 observations provide an initial delineation of the behavioral phenotype of GRIN2B mutation carriers.
23665428 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
23660601 SLC1A1, GRIN2B, and interactions between the two may potentially confer a susceptibility to obsessive-compulsive symptoms in schizophrenia patients receiving clozapine
23648631 The presence of NR2B immunoreactivity in oocytes may account for the fact that anti-NMDAR encephalitis predominantly affects young females.
23271275 B7T inhibition of NMDA current mediated by NR1/NR2B receptor.
23267846 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
23229837 SNPs in GRIN2B show significant association with neuroticism and borderline association with anti-social personality disorder.
23201971 vertebrate behavior and synaptic signaling acquired increased complexity from the duplication and diversification of ancestral GluN2a and GLUN2b genes.
22986046 This study does not support the primary hypothesis that rare de novo coding mutations at GRIN2B contribute to schizophrenia.
22940423 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
22936815 Ifenprodil decreased GluN2B-containing NMDA receptor equilibrium open probability.
22850629 The results of this study suggest that specific genetic variants in a subset of glutamatergic (GRIN2B) and polyaminergic (ODC1) neurosystem genes may be of importance in certain suicidal subjects.
22833681 tau interacts in a phosphorylation-dependent manner with the PSD95-Fyn-NMDA receptor complex at the postsynaptic site
22833210 One de novo mutation is identified in GRIN2B in a patient with autism spectrum disorder.
22832729 This suggested that LID, TD and HD might arise from the same neuronal pathways, but TD results from a different mechanism.
22742935 The incubation of hippocampal slices with NMDA Receptor 2B antagonists blunted the effect of creatine on Na(+),K(+)-ATPase activity.
22711533 key amino acid residues within both NR1 and NR2B M3 domains contribute to the regulation of the surface expression of unassembled NR1 and NR2 subunits
22610100 NR2B as a novel proteolytic substrate of tPA, where tPA may directly interact with NR2B subunits leading to a change in pharmacological properties of NR2B-containing NMDA receptors.
22578441 results suggest the lack of an association between OCD and polymorphisms in the 3'-UTR of GRIN2B in a Chinese Han population.
22552781 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
22484476 results show that variations in GRIN2B have to be taken into consideration when examining attentional processes.
22479519 analysis of selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection
22433450 some single nucleotide polymorphisms of the GRIN2B gene were significantly associated with the presence of contamination obsessions and cleaning compulsions
22326929 There was a statistically significant associations between autism spectrum disorders and haplotypes in GRIN2B.
22142193 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
22114277 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
21948112 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
21919190 results suggest that genetic variation in the 3' region of GRIN2B is associated with schizophrenia and that genetic variation in this region interacts with maternal HSV-2 seropositivity, affecting the risk of schizophrenia in the offspring later in life
21827795 The findings of this study suggested that variation in GRIN2B contributes to the interindividual variability of language lateralization.
21789901 induction of LTD in layer II/III pyramidal neurons of the young rat visual cortex is NMDAR-dependent and requires NR2B-containing NMDARs, not NR2A-containing NMDARs.
21753020 individuals carrying the G allele in the rs1805247 GRIN2B SNP show greater intracortical facilitation and greater long-term potentiation-like cortical plasticity after intermittent-burst stimulation.
21749895 Females with a CC allele in rs1806201 made less use both of win-stay strategy & demonstrated more exploratory behaviour during gambling task execution
21704719 Post-translational modification of NMDA receptor GluN2B subunit and its roles in chronic pain and memory
21670103 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
21639937 Aberrant methylation of NMDAR2B, detected in 131 of 216 non-small-cell lung tumors, was inversely correlated with protein expression in 20 randomly examined NSCLCs. It was an independent prognostic factor in squamous cell carcinoma cases.
21597037 N-methyl-d-aspartate receptor plays a critical role in preserving the normal epithelial phenotype and modulating tubular epithelial-mesenchymal transition.
21491143 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
20957330 Psychosis and relapse in bipolar disorder are related to GRM3, DAOA, and GRIN2B genotype in a Caucasian and mixed-ancestry South African pilot study.
20957330 Observational study of gene-disease association. (HuGE Navigator)
20945430 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20939817 Powerful inhibitors of the NR2B N-Methyl-D-Aspartate receptor are described for the treatment of the CNS diseases. Review.
20890276 Mutations cause mental neurodevvelopmental disordes such as epilepsy and mental retardation.
20882066 GRIN2B C2664T variant polymorphism is not associated with Alzheimer's disease in a Chinese Han population of Shanghai City.
20882066 Observational study of gene-disease association. (HuGE Navigator)
20859245 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20848605 NR2B is not involved in amygdala hyperexcitability of patients with temporal lobe epilepsy.
20537986 Forebrain NR2B over-expression has different effects on gustatory learning and memory in transgenic mice, which are only sensitive to novel but unfamiliar tastes.
20537720 This study provided evidence that GRIN2B gene is association with bipolar disorder in the Chinese Han Population.
20537720 Observational study of gene-disease association. (HuGE Navigator)
20468064 Observational study of gene-disease association. (HuGE Navigator)
20464528 Observational study of gene-disease association. (HuGE Navigator)
20438806 Polymorphisms in the GRIN1 and GRIN2B genes may serve as potential biomarkers for a reduced risk of PD among the Chinese population in Taiwan.
20438806 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20427279 Dominant role for NR2B in regulating the trafficking of triheteromeric NMDA receptors in vivo in the brain.
20421849 Both prepulse inhibition and habituation were decreased significantly in patients with schizophrenia. In addition, we observed a significant effect of GRIN2B genotype on habituation
20399867 results provide first insight into cognitive-neurophysiological effects of the GRIN2B C2664T polymorphism; dissociation obtained may be due to a differential importance of NMDARs for glutamatergic neural transmission in different striatal compartments
20399867 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20347576 NR2B-containing NMDA receptor transport could be selectively compromised in schizophrenia, and that these changes likely involve altered NR2B function in a subset of cortical neurons.
20201926 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20197096 a nucleotide polymorphism in the GRIN2B gene was associated with bilateral temporal lobe volume in Alzheimer's disease patients
20197096 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20175224 our results suggest altered endoplasmic reticulum exit and forward trafficking of NR2B-containing NMDA receptors in prefrontal cortex neurons in chizophrenia
19874574 Observational study of gene-disease association. (HuGE Navigator)
19784770 Functional NMDA receptors are expressed by breast cancer and are important agents for maintaining cell growth and viability.
19726645 NR2B NMDA receptor is critically involved in organization of postsynaptic macromolecular complexes, regulation of actin cytoskeleton and formation of dendritic spines in hippocampal pyramidal cells.
19605943 polymorphisms of the GRIN2B gene did not show an association with the treatment response to lithium in bipolar patients.
19605943 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19591125 variation within GRIN2B may contribute to the genetic background of specific cognitive processes which are correlates of the dyslexia phenotype
19591125 Observational study of gene-disease association. (HuGE Navigator)
19562769 Carriage of either CC genotype of GRIN2B was identified as a risk factor for impulse control and related behaviors. Variants of GRIN2B may be associated with the appearance of impulse control and related behaviors in Parkinson's disease.
19562769 Observational study of gene-disease association. (HuGE Navigator)
19526283 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
19523047 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19453375 Phosphorylation or a phosphorylation mimicking mutation on NR2B (NR2B-S1303D) abolishes the Ca(2+)/calmodulin-independent binding whereas it allows the Ca(2+)/calmodulin-dependent binding of alpha-CaMKII in vitro.
19367581 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19350219 The severity of alcohol drinking pattern, measured by lifetime drinking and daily ethanol intake, was negatively correlated with the methylation of a defined cluster of five CPG-sites within the NR2B promoter.
19328558 Observational study of gene-disease association. (HuGE Navigator)
19324536 These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.
19324536 Observational study of gene-disease association. (HuGE Navigator)
19279257 A validated murine genetic model of Huntington disease in a transgenic line is the first direct in vivo evidence of NR2B-NMDAR-mediated excitotoxicity in the context of Huntington disease.
19268276 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
19192303 A positive feedback control of NR2B receptor subunit is proposed to explain cortical sensitization involved in chronic pain, but not learning and memory.
19156168 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19095845 A comparison of the molecular bases for NR1/NR2B receptor inhibition versus immobilizing activities of volatile aromatic anesthetics.
19088076 SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression.
19086053 Observational study of gene-disease association. (HuGE Navigator)
19036954 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
19020013 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
19011431 An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.
19005876 In linkage disequilibrium analysis we did not find linkage between the three polymorphisms of GRIN2B gene. The polymorphisms of GRIN2B gene analysed in this study are not likely to be associated with bipolar disorder.
19005876 Observational study of gene-disease association. (HuGE Navigator)
18991843 Data show that expression of NMDA receptor NR1, NR2A, and NR2B subunits is significantly lower in brains of cirrhotic alcoholics than in the corresponding areas in both controls and alcoholics without co-morbid disease.
18983893 Our study suggests that the -421C allele may induce lower GRIN2B transcriptional activity and NR2B protein expression, thus it is associated with AD.
18983893 Observational study of gene-disease association. (HuGE Navigator)
18976975 Knockdown of glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells
18836292 analysis of the role of the fourth membrane domain of the NR2B subunit in the assembly of the NMDA receptor
18606955 Observational study of gene-disease association. (HuGE Navigator)
18583979 Meta-analysis of gene-disease association. (HuGE Navigator)
18303265 GRIN2B gene is associated with Alzheimer's disease.
18303265 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18068304 the synaptic NMDA receptor extracellular signal-regulated kinase activation pathway is coupled to both NR2A and NR2B containing receptors
18007143 results on chromosome 12p support GRIN2B as a candidate gene for bipolar disorder that needs further investigation
17962190 The interaction between NR2B subunit and Mind bomb-2 reveal a possible mechanism for the regulation of NMDAR function involving both phosphorylation and ubiquitination.
17942280 Laser capture microdissection combined with quantitative PCR was used to examine the expression of AMPA (GRIA1-4) and NMDA (GRIN1, 2A and 2B) subunit mRNA levels in Layer II/III and Layer V pyramidal cells
17669510 genetic variations in the human GRIN2B gene probably do not play a major role in susceptibility to, or severity of Tardive dyskinesia
17620329 NMDAR2B methylation is a common and important biologically relevant event in gastric cancer progression
17569088 NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner.
17569088 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17506987 postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA are upregulated in temporal lobe tissue of epilepsy
17506933 The results clearly indicate that D1R-modulated NR1a/NR2B receptor function depends on PSD-95 and is subjected to the regulation of PKA and PKC.
17360663 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
17255096 the three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit
17224684 Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator)
17224684 The results show evidence of a statistically significant association for GRIN2B. The association seems weaker, but nonetheless interesting
17010153 Observational study of gene-disease association. (HuGE Navigator)
17010153 data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait.
16911840 Observational study of gene-disease association. (HuGE Navigator)
16911840 These findings suggest new candidate SNPs(rs1806201) in GRIN2B for studying the genetic susceptibility to alcoholism.
16870468 Results describe the successful replacement of murine N-methyl-d-aspartate receptor (NR)2B gene function by "knocking-in" a chimeric human NR2A/B cDNA containing the minimal domain abolishing ifenprodil binding into the endogenous NR2B locus.
16766085 Observational study of gene-disease association. (HuGE Navigator)
16697675 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
16549338 Observational study of gene-disease association. (HuGE Navigator)
16549338 The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
16489129 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
16481105 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
16380905 Observational study of gene-disease association. (HuGE Navigator)
16289038 These results demonstrate that human T lymphocytes express the NR2B subunit of NMDA receptors, which are functionally active in controlling cell activation.
16266783 Observational study of gene-disease association. (HuGE Navigator)
15866054 novel mechanism for Ca2+-dependent negative-feedback regulation of NR2B-containing NMDARs in a CaMKII activity- and autophosphorylation-dependent manner that may modulate NMDAR-mediated synaptic plasticity
15841096 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15841096 the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.
15812607 Observational study of gene-disease association. (HuGE Navigator)
15749123 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
15742215 Observational study of gene-disease association. (HuGE Navigator)
15742215 NR2B subtypes mainly expressed in the striatum, may influence the variability in age of onset of Huntington disease.
15542698 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15211626 Observational study of gene-disease association. (HuGE Navigator)
15211626 results suggest that GRIN2B single nucleotide polymorphisms might be linked with susceptibility to schizophrenia
15180478 Reviews the role of altered structure and function of NMDA receptors after ethanol exposure and summarizes the recent data about the activity of NR2B subunit selective NMDA receptor antagonists in model systems related to alcoholism.
15083261 These results provide evidence that GRIN2B may be associated with susceptibility to OCD.
15030493 Increased coassembly of NR2B and NR1 with PSD-95 may underlie one of the cellular mechanisms that contributes to in situ increased hyperexcitability, leading to seizure generation in focal cortical dysplasia.
14662797 NR2B was located in the midpiece of sperm, whereas GLT1 mainly existed in the head
14644469 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
14573320 Observational study of gene-disease association. (HuGE Navigator)
14573320 Variants in NMDAR genes are associated with alcoholism and related traits.
12893641 human cerebral endothelial cells express the message and protein for NMDA receptors.
12824739 Observational study of gene-disease association. (HuGE Navigator)
12824739 The results show that GRIN2B genetic variations are not a major risk factor for treatment-refractory schizophrenic patients, but may influence the effect of clozapine during treatment.
12775422 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
12556902 Observational study of gene-disease association. (HuGE Navigator)
12476325 Observational study of gene-disease association. (HuGE Navigator)
12476325 identification of a novel variant of the human gene promoter region and its possible association with schizophrenia
12414113 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
12127670 The levels of Nr2B mRNA are decreased in Alzheimer disease hippocampus and entorhinal cortex compared to controls.
12082569 Observational study of gene-disease association. (HuGE Navigator)
11979061 Observational study of gene-disease association. (HuGE Navigator)
11956967 Observational study of gene-disease association. (HuGE Navigator)
11956967 It is unlikely that the GRIN2B C2664T polymorphism plays a substantial role in conferring susceptibility to Parkinson's disease in the Chinese population.
11844890 Observational study of gene-disease association. (HuGE Navigator)
11844890 hypothesis that the allelic variant (C2664T) of the NR2b confers susceptibility to AD .
11807413 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
11807413 NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia
11606043 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
11483648 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
11317224 Observational study of gene-disease association. (HuGE Navigator)
10555109 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
10448428 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
10197777 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
9745929 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
9651389 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8955056 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8845955 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8822372 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8821747 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8804048 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8724036 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8581564 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8563977 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
7695237 The gene expression of GRIN2B is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells

AA Sequence

MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVEL      1 - 70
VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDES     71 - 140
SMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLD    141 - 210
DGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISV    211 - 280
SYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLS    281 - 350
FSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE    351 - 420
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKI    421 - 490
NGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWV    491 - 560
MMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKI    561 - 630
MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYA    631 - 700
EMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDS    701 - 770
GWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH    771 - 840
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMAN    841 - 910
LSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNV    911 - 980
YQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYS    981 - 1050
GHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHK   1051 - 1120
RYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVV   1121 - 1190
SGVPAPWEKNLTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL   1191 - 1260
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRF   1261 - 1330
MDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHG   1331 - 1400
SKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKNPRAFNGSSN   1401 - 1470
GHVYEKLSSIESDV                                                           1471 - 1484
//

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18991843 2008 The expression of NMDA receptor subunit mRNA in human chronic alcoholics.
18983893 2009 Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population.
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18303265 2008 Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease.
18068304 2008 Temperature dependence of NR1/NR2B NMDA receptor channels.
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17997397 2007 Analysis of NR3A receptor subunits in human native NMDA receptors.
17962190 2008 Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner.
17942280 2007 Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia.
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17569088 2007 NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner.
17506987 2007 Upregulated expression of postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA in temporal lobe tissue of epilepsy.
17506933 2007 Requirement of PSD-95 for dopamine D1 receptor modulating glutamate NR1a/NR2B receptor function.
17255096 2007 A three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit.
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17010153 2007 Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder.
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16436603 2006 Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.
16380905 2005 Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.
16289038 2005 Human T lymphocytes express N-methyl-D-aspartate receptors functionally active in controlling T cell activation.
16266783 2006 Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes.
16120608 2005 Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.
15866054 2005 CaMKIIalpha enhances the desensitization of NR2B-containing NMDA receptors by an autophosphorylation-dependent mechanism.
15841096 2005 An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray.
15812607 2005 Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens.
15742215 2005 NR2A and NR2B receptor gene variations modify age at onset in Huntington disease.
15673434 2005 A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins.
15542698 2004 Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians.
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15211626 2004 Variations in the NMDA receptor subunit 2B gene (GRIN2B) and schizophrenia: a case-control study.
15180478 2004 The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependence.
15083261 2004 Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study.
15030493 2004 Increased numbers of coassembled PSD-95 to NMDA-receptor subunits NR2B and NR1 in human epileptic cortical dysplasia.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14662797 Identification of glutamate receptors and transporters in mouse and human sperm.
14644469 2004 The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site.
14622581 2003 The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.
14573320 2003 Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits.
12893641 2003 Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor.
12890763 2003 Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein.
12857875 2003 p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling.
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12738960 2003 NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex.
12650977 2003 Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha) reversibly targets to and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in cerebral ischemia and reperfusion in hippocampus of rats.
12556902 2003 No association of alcohol dependence with a NMDA-receptor 2B gene variant.
12531901 2003 RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.
12524444 2003 Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12476325 2002 Identification of a novel variant of the human NR2B gene promoter region and its possible association with schizophrenia.
12414113 2002 Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor.
12391275 2002 Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits.
12191494 2002 Immunohistochemical localization of N-methyl-D-aspartate receptor subunits in the adult murine hippocampal formation: evidence for a unique role of the NR2D subunit.
12147342 2002 Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII.
12127670 2002 N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease.
12082569 2002 Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.
11997254 2002 Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses.
11979061 2002 Dopamine D2 receptor and N-methyl-D-aspartate receptor 2B subunit genetic variants and intelligence.
11937501 2002 Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.
11799243 2002 Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors.
11679592 2002 Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain.
11606043 2001 HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons.
11588171 2001 An NMDA receptor signaling complex with protein phosphatase 2A.
11483655 2001 Tyrosine phosphorylation of the N-methyl-D-aspartate receptor by exogenous and postsynaptic density-associated Src-family kinases.
11483648 2001 HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity.
11459059 2001 Interaction with the NMDA receptor locks CaMKII in an active conformation.
11317224 2001 Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia.
11306676 2001 Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.
11029657 2000 The colorectal tumour suppressor APC is present in the NMDA-receptor-PSD-95 complex in the brain.
11024032 2001 Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.
10884433 2000 Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions.
10846184 2000 Src-mediated tyrosine phosphorylation of NR2 subunits of N-methyl-D-aspartate receptors protects from calpain-mediated truncation of their C-terminal domains.
10748157 2000 Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.
10620012 1999 Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase.
10488080 1999 PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain.
10485705 1999 Genetic enhancement of learning and memory in mice.
10480938 1999 Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors.
10479680 1999 Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.
10458595 1999 The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains.
10381539 1999 Brain-derived neurotrophic factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density.
10373510 1999 Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.
10341223 1999 Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex.
10197777 1999 Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats.
9806853 1998 Fine-scale physical map of the 11q21 region surrounding the human DLG2 locus, the gene encoding Chapsyn-110.
9651389 1998 HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism.
9647694 1998 CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.
9620694 1998 A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II.
9581762 1998 CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90.
9547169 1997 mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit.
9481670 1998 Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.
9427503 1997 Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies.
9326658 1997 Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein.
9231720 1997 The N-methyl-D-aspartate receptor subunits NR2A and NR2B bind to the SH2 domains of phospholipase C-gamma.
9009191 1997 Competitive binding of alpha-actinin and calmodulin to the NMDA receptor.
8940188 1996 Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor.
8780649 1996 SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo.
8768735 1996 Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.
8665664 1995 Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.
8615909 1996 Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
8601796 1996 Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases.
8163463 1994 Transmembrane topology of the glutamate receptor subunit GluR6.
8139656 1994 Changing subunit composition of heteromeric NMDA receptors during development of rat cortex.
7999784 1995 Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein.
7959773 1994 Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12.
7695237 1995 Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.
7569905 1995 Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.
1350383 1992 Heteromeric NMDA receptors: molecular and functional distinction of subtypes.