Property Summary

NCBI Gene PubMed Count 225
Grant Count 725
R01 Count 420
Funding $97,781,319.51
PubMed Score 1954.56
PubTator Score 690.80

Knowledge Summary

Patent (26,145)

TINX Plot

  Disease Relevance (51)

Disease Z-score Confidence
Schizophrenia 501 5.479 2.7
Toxic encephalopathy 131 5.286 2.6
Alzheimer's disease 644 4.636 2.3
Epilepsy 346 4.502 2.3
Parkinson's disease 364 4.435 2.2
Alcohol dependence 107 4.249 2.1
Huntington's disease 72 4.159 2.1
Cerebrovascular disease 231 4.107 2.1
Autistic Disorder 320 3.851 1.9
Encephalitis 54 3.658 1.8
obsessive-compulsive disorder 34 3.624 1.8
Bipolar Disorder 266 3.433 1.7
Fetal alcohol syndrome 10 3.423 1.7
Opiate dependence 12 3.24 1.6
Intellectual disability 573 3.197 1.6
Dementia 129 3.193 1.6
Major Depressive Disorder 106 3.163 1.6
Pain agnosia 99 3.111 1.6
Substance abuse 55 3.055 1.5
Alcoholism 14
Arteriosclerotic Parkinsonism 8
Carcinoma 2,147 1.0
Child Development Disorders, Pervasive 55
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTIL... 1 
Extrapyramidal disease 8
General anesthesia 53
Hyperalgesia 71
Hypotension 53
Influenza A Prevention 7
Influenza due to Influenza A virus 7
Lennox-Gastaut syndrome 34
Local anesthesia 40
MENTAL RETARDATION, AUTOSOMAL DOMINANT 6 1
Moderate to Severe Alzheimer's Type Deme... 5 
Parkinsonism 19
Postencephalitic parkinsonism 12
Simple partial seizure 26
West Syndrome 23
adult high grade glioma 2,148
astrocytic glioma 2,241
atypical teratoid / rhabdoid tumor 4,369
ependymoma 2,514
glioblastoma 5,572
medulloblastoma 1,524
medulloblastoma, large-cell 6,234
non primary Sjogren syndrome sicca 840
oligodendroglioma 2,849
osteosarcoma 7,933
pilocytic astrocytoma 3,086
primitive neuroectodermal tumor 3,031
psoriasis 6,685

Expression

  Differential Expression (13)

Disease log2 FC p
astrocytic glioma -2.500 0.001
ependymoma -2.800 0.001
oligodendroglioma -2.300 0.003
glioblastoma -3.300 0.000
osteosarcoma -1.067 0.000
medulloblastoma -2.900 0.000
atypical teratoid / rhabdoid tumor -3.200 0.000
medulloblastoma, large-cell -2.800 0.003
primitive neuroectodermal tumor -2.600 0.002
adult high grade glioma -2.800 0.000
pilocytic astrocytoma -1.700 0.001
non primary Sjogren syndrome sicca -1.100 0.029
psoriasis -1.600 0.000

Synonym

Accession Q13224 Q12919 Q13220 Q13225 Q14CU4 Q9UM56 GluN2B
Symbols MRD6
NR2B
hNR3
EIEE27
GluN2B
NMDAR2B

Gene

PDB

1S11   1S2S   2IPV   5EWJ   5EWL   5EWM  

  TechDev Info (1)

Susumu Tomita Examining potential modulators

Gene RIF (223)

PMID Text
26912815 GluN2B appears to exhibit allosteric regulation/inhibition by two distinct classes of antagonists; data from in silico docking suggest that GluN2B-selective antagonists broadly divide into two distinct classes according to binding pose.
26884337 both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
26819771 GRIN2B (rs7301328) was significantly associated with disruptive behavior in adolescents.
26627941 GRIN2B polymorphisms do not influence Parkinson disease age of onset in the US Caucasian population.
26584860 Knockdown of PKD1 did not affect NMDAR internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR-mediated synaptic functions.
26321256 GRIN2B encodes the NR2 subunit of NMDA receptors, which are a class of ionotropic glutamate receptors involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission.
26252487 ligand binding to cell surface GD2 induces rapid and transient activation of Src-family kinases, followed by Src-dependent phosphorylation of NMDA-receptor NR2B subunits selectively.
26081945 GFAP peaks early during haemorrhagic brain lesions (at significantly higher levels), and late in ischaemic events, whereas antibodies against NR2 RNMDA have significantly higher levels during ischemic stroke at all time-points.
26020650 Study provides evidence of an association between GRIN2B polymorphisms and Schizophrenia susceptibility and symptoms in the Han Chinese population.
25896831 Polymorphisms in DRD1, DRD2 and GRIN2B confer increased risk of impulse control problems among PD patients.
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AA Sequence

MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVEL      1 - 70
VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDES     71 - 140
SMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLD    141 - 210
DGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISV    211 - 280
SYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLS    281 - 350
FSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE    351 - 420
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKI    421 - 490
NGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWV    491 - 560
MMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKI    561 - 630
MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYA    631 - 700
EMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDS    701 - 770
GWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH    771 - 840
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMAN    841 - 910
LSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNV    911 - 980
YQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYS    981 - 1050
GHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHK   1051 - 1120
RYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVV   1121 - 1190
SGVPAPWEKNLTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL   1191 - 1260
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRF   1261 - 1330
MDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHG   1331 - 1400
SKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKNPRAFNGSSN   1401 - 1470
GHVYEKLSSIESDV                                                           1471 - 1484
//

Text Mined References (227)

PMID Year Title
26912815 2016 A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
26884337 2016 Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.
26819771 2016 Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents.
26627941 2016 Association of Parkinson disease age of onset with DRD2, DRD3 and GRIN2B polymorphisms.
26584860 2015 Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors.
26321256 2015 The role of GRIN2B in Tourette syndrome: Results from a transmission disequilibrium study.
26252487 2015 Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology.
26081945 2015 GFAP and antibodies against NMDA receptor subunit NR2 as biomarkers for acute cerebrovascular diseases.
26020650 2015 Association Study of N-Methyl-D-Aspartate Receptor Subunit 2B (GRIN2B) Polymorphisms and Schizophrenia Symptoms in the Han Chinese Population.
25896831 2015 DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson's disease patients.
More...