Property Summary

NCBI Gene PubMed Count 138
Grant Count 231
R01 Count 164
Funding $17,116,020.1
PubMed Score 314.66
PubTator Score 202.26

Knowledge Summary

Patent (12,902)

Expression

  Differential Expression (6)

Disease log2 FC p
ependymoma 1.300 0.010
medulloblastoma 1.800 0.000
atypical teratoid / rhabdoid tumor 1.500 0.000
glioblastoma 1.400 0.000
medulloblastoma, large-cell 1.400 0.002
primitive neuroectodermal tumor 1.400 0.000

Synonym

Accession Q13164 Q16634 Q59F50 Q6QLU7 Q7L4P4 Q969G1 Q96G51 MAP kinase 7
Symbols BMK1
ERK4
ERK5
PRKM7

Gene

PDB

4IC7   2Q8Y   4B99   4IC8   4ZSG   4ZSJ   4ZSL   5BYY   5BYZ  

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (105)

PMID Text
26617753 data implied the up-regulated MAPK7 might contribute to ovarian cancer metastasis
26347473 The TRAF4-ERK5 is a dominant pathway in human skin squamous cell carcinoma.
26307013 Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.
26302753 Our findings define ERK5 as a novel kinase that modulates the levels of TCR/CD3 at the cell surface by promoting CD3zeta degradation and TCR/CD3 recovery after TCR stimulation.
26272601 The results pf this study indicated that BMK1 modulation by miR-429 has an important function in glioma invasion both in vitro and in vivo.
26177962 we demonstrated for the first time that ERK5 positively regulated CS-mediated EMT in urothelial cells, as evidenced by the findings that CS promoted ERK5 activation and that the CS-triggered alteration in the EMT phenotype was reversed by ERK5 inhibition
26040563 data highlight a broader role for dysregulated MAPK7 in driving tumorigenesis within niche populations of highly prevalent tumor types, and describe current efforts in establishing a robust drug discovery screening cascade.
26032256 This study reveals a novel role for the ERK5-MEF2 cascade, linking bFGF-induced PAI-1 expression and subsequent mitogenic processes in lung fibroblasts.
25965818 ERK5 negatively regulates cigarette smoke-mediated pulmonary epithelial mesenchymal transformation.
25689862 Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription
More...

AA Sequence

MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVS      1 - 70
SARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLM     71 - 140
ESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS    141 - 210
PAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGT    211 - 280
PSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY    281 - 350
HDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP    351 - 420
SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSR    421 - 490
LRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLV    491 - 560
LSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQ    561 - 630
PACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAP    631 - 700
QSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADS    701 - 770
ASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP                            771 - 816
//

Text Mined References (142)

PMID Year Title
26617753 2015 Role of MAPK7 in cell proliferation and metastasis in ovarian cancer.
26347473 2015 A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis.
26307013 2015 Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.
26302753 2016 Dual role of ERK5 in the regulation of T cell receptor expression at the T cell surface.
26272601 2015 miR-429 inhibits glioma invasion through BMK1 suppression.
26177962 2015 ERK5 positively regulates cigarette smoke-induced urocystic epithelial-mesenchymal transition in SV?40 immortalized human urothelial cells.
26040563 2015 Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma.
26032256 2015 ERK5 regulates basic fibroblast growth factor-induced type 1 plasminogen activator inhibitor expression and cell proliferation in lung fibroblasts.
25965818 2015 ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial-mesenchymal transition.
25689862 2015 Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription.
More...