Tchem MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5

Protein Summary

Description

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q13163
• B4DE43
• Q92961
• Q92962
• MAP kinase kinase 5

Gene Name

• MAP2K5

Ensembl ID

• ENST00000178640
• ENSP00000178640
• ENSG00000137764
• ENST00000354498
• ENSP00000346493
• ENST00000395476
• ENSP00000378859

Symbol

• MEK5
• MKK5
• PRKMK5
• MEK5
• MAPKK5
• PRKMK5
• HsT17454

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	0.96
molecular function	0.96
drug perturbation	0.87
histone modification site profile	0.86

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste7 Family / Dual Specificity Mitogen-activated Protein Kinase Kinase 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.44   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 519   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.44   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 519   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3