Property Summary

NCBI Gene PubMed Count 50
PubMed Score 101.47
PubTator Score 93.43

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
posterior fossa group A ependymoma 1511 1.29535312355332E-15
astrocytoma 1493 4.48623101035011E-15
oligodendroglioma 2849 9.11121128918227E-14
pediatric high grade glioma 2712 1.705480498438E-9
pilocytic astrocytoma 3086 8.24128202903905E-9
atypical teratoid/rhabdoid tumor 1095 6.7963669204097E-8
sonic hedgehog group medulloblastoma 1482 2.3867999369816E-7
ulcerative colitis 2087 1.61944583639859E-5
Amyotrophic Lateral Sclerosis 432 1.76800339052941E-5
lung cancer 4473 2.01984597670184E-5
interstitial cystitis 2299 5.3055794188288E-5
medulloblastoma, large-cell 6234 7.98772450343665E-5
glioblastoma 5572 3.47946193579164E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00104422935851931
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00569014755331729
pancreatic cancer 2300 0.00728608263444307
acute myeloid leukemia 785 0.0138038540298878
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0144727549901831
ovarian cancer 8492 0.0156729573654696
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0161806636246937
colon cancer 1475 0.0218446147927136
non primary Sjogren syndrome sicca 840 0.0304650487508306
diabetes mellitus 1663 0.0400755360484146
Breast cancer 3099 0.0486949215504097
Disease Target Count Z-score Confidence
Scurvy 10 3.485 1.7



Accession Q13162 Q6FHT3
Symbols PRX-4


PANTHER Protein Class (2)


2PN8   3TJB   3TJF   3TJG   3TJJ   3TJK   3TKP   3TKQ   3TKR   3TKS   4RQX  

  Ortholog (13)

Gene RIF (41)

26261544 Positive Prx 4 expression is significantly correlated with recurrence and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma.
25137134 An off-pathway reaction in the Prx4-mediated oxidative protein folding.
25122762 these data suggest an important role of Prdx4 in maintaining insulin levels and improving the ER folding capacity also under conditions of a high insulin requirement.
24893865 Findings suggest that elevated serum Prx4 levels are associated with a higher risk of incident type 2 diabetes
24617620 there is a significant difference in concentration of Prx4 between cardiac arrest patients with good and poor outcome
24586984 Prx4 is a circulating antioxidant and is independently associated with increased risk of cardiovascular and all-cause mortality in T2DM.
24450625 The structure and function of PRDX4 as well as its sensitivity to hyperoxidation. [Review]
24403061 peroxiredoxin IV recycling in the endoplasmic reticulum is much less efficient than in the cytosol or mitochondria, leading to the protection of peroxiredoxin IV from hyperoxidation.
24098506 expression of PRDX4 in PCOS ovaries appeared to be mediated through oxidative stress in GCs. We reported that the deficiency of antioxidant PRDX4 was associated with pathophysiological mechanism of PCOS.
23979138 Data indicate that protein disulfide isomerase (PDI) and ERp44 dynamically localize Ero1alpha and peroxiredoxin 4 in early secretory compartment (ESC).

AA Sequence


Text Mined References (54)

PMID Year Title
26261544 2015 Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25137134 2014 A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding.
25122762 2014 Peroxiredoxin 4 improves insulin biosynthesis and glucose-induced insulin secretion in insulin-secreting INS-1E cells.
24893865 2014 Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study.
24617620 2014 CT-proAVP (copeptin), MR-proANP and Peroxiredoxin 4 after cardiac arrest: release profiles and correlation to outcome.
24586984 2014 Serum peroxiredoxin 4: a marker of oxidative stress associated with mortality in type 2 diabetes (ZODIAC-28).
24450625 2014 Regulating the level of intracellular hydrogen peroxide: the role of peroxiredoxin IV.
24403061 2014 Lack of an efficient endoplasmic reticulum-localized recycling system protects peroxiredoxin IV from hyperoxidation.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.