| Tbio | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 |
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| glioblastoma | 5792 | 4.0e-09 |
| lung adenocarcinoma | 2716 | 9.9e-08 |
| medulloblastoma, large-cell | 6241 | 2.2e-05 |
| adult high grade glioma | 3801 | 2.2e-05 |
| group 3 medulloblastoma | 4104 | 3.3e-04 |
| ovarian cancer | 8520 | 3.8e-04 |
| astrocytoma | 1146 | 4.5e-03 |
| non primary Sjogren syndrome sicca | 891 | 1.9e-02 |
| lung cancer | 4740 | 3.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 2.2e-05 |
| astrocytoma | 1.200 | 4.5e-03 |
| glioblastoma | 1.100 | 4.0e-09 |
| group 3 medulloblastoma | 1.100 | 3.3e-04 |
| lung adenocarcinoma | 1.100 | 9.9e-08 |
| lung cancer | 1.800 | 3.2e-02 |
| medulloblastoma, large-cell | 1.600 | 2.2e-05 |
| non primary Sjogren syndrome sicca | 1.200 | 1.9e-02 |
| ovarian cancer | 1.600 | 3.8e-04 |
MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQDDILKRLYELK 1 - 70 AAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHR 71 - 140 LLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGE 141 - 210 GNIARFLFSLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVV 211 - 280 LWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK 281 - 320 //
