Property Summary

NCBI Gene PubMed Count 234
PubMed Score 115.46
PubTator Score 299.79

Knowledge Summary

Patent (6,521)


  Disease Sources (4)

Disease Target Count P-value
malignant mesothelioma 3163 3.50136311408512E-6
head and neck cancer and chronic obstructive pulmonary disease 237 2.13944199494458E-4
psoriasis 6685 2.51195398729698E-4
tuberculosis 1563 9.67190485853573E-4
adrenocortical carcinoma 1427 0.0031047589741711
active Crohn's disease 918 0.00313868474569366
active ulcerative colitis 477 0.00700187168476155
osteosarcoma 7933 0.00890201082530449
invasive ductal carcinoma 2950 0.0110465530265479
ductal carcinoma in situ 1745 0.0169846322198502
Disease Target Count Z-score Confidence
Metabolic syndrome X 155 0.0 2.0
Disease Target Count Z-score Confidence
Atherosclerosis 275 4.202 2.1
Lipid metabolism disorder 102 3.13 1.6


  Differential Expression (10)

Disease log2 FC p
malignant mesothelioma 1.400 0.000
psoriasis -1.500 0.000
osteosarcoma -1.876 0.009
adrenocortical carcinoma -1.250 0.003
tuberculosis 1.100 0.001
active Crohn's disease -1.493 0.003
active ulcerative colitis -1.109 0.007
ductal carcinoma in situ -1.100 0.017
invasive ductal carcinoma -1.200 0.011
head and neck cancer and chronic obstruc... 1.100 0.000


Accession Q13133 A8K3J9 D3DQR1 Q8IW13 Q96H87
Symbols LXRA



1UHL   3IPQ   3IPS   3IPU   5AVI   5AVL   5HJS  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid

  TechDev Info (2)

Steve Finkbeiner Neuron specific phenotypes being screened
Jun Qin Signaling network evaluation of transcript factor crosstalk via catTRE/MS

MLP Assay (2)

AID Type Active / Inconclusive / Inactive Description
2277 screening 14 / 0 / 0 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors.
504934 other 1 / 0 / 0 Late stage assay provider results from the probe development effort to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors

Gene RIF (206)

26814197 these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1.
26692490 In conclusion, our data indicate that HNF-4alpha may have a wider role in cell and plasma cholesterol homeostasis by controlling the expression of LXRalpha in hepatic cells.
26669941 LXR-alpha might downregulate S1PR2 expression via miR-130a-3p in quiescent HUVECs. Stimulation of TNF-alpha attenuates the activity of LXR-alpha and results in enhanced S1PR2 expression.
26602218 Intestinal activation of LXR reduces the production of chylomicrons by a mechanism dependent on the apical localization of SR-B1.
26595172 Studied the role of LXRalpha with Wnt/beta-catenin signaling in adipogenesis of MSCs.
26469385 HIV-1 MA activates NR1H3 signaling in primary hepatocytes
26379423 Suggest that blocking cholesterol deposition and inhibiting the LXRalpha pathway-induced inflammatory response might be one of the main mechanisms by which anthocyanins exert their protective effects in diabetic nephropathy.
26261553 Lipoxin A4 increases ABCA1 expression and promotes cholesterol efflux through LXRalpha pathway in THP-1 macrophage-derived foam cells.
26160456 These results identify LXRalpha as a key cardiac transcriptional regulator that helps orchestrate an adaptive metabolic response to chronic cardiac stress.
25980575 This study provides the first evidence to show LXR activation reduces cadmium-induced apoptotic cell death of human renal proximal tubular cells by inhibition of reactive oxygen species production and JNK activation.

AA Sequence

HSEQVFALRLQDKKLPPLLSEIWDVHE                                               421 - 447

Text Mined References (235)

PMID Year Title
26814197 2016 TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors.
26692490 2016 Transcriptional regulation of the human Liver X Receptor ? gene by Hepatocyte Nuclear Factor 4?.
26669941 2016 Liver X receptor-? and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells.
26602218 2016 Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1.
26595172 2016 Nuclear hormone receptor LXR? inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling.
26379423 2015 Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXR? pathway in HK-2 cells.
26261553 2015 Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXR? signaling pathway in THP-1 macrophage-derived foam cells.
26160456 2015 Cardiac LXR? protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization.
26120082 2015 Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis.
25980575 2015 Activation of liver X receptors inhibits cadmium-induced apoptosis of human renal proximal tubular cells.