Tbio KLF10 Krueppel-like factor 10

Protein Summary

Description

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q13118
• A8MVH0
• B2R794
• L0R4P6
• L0R679
• O75411
• Q503B2

Gene Name

• KLF10

Ensembl ID

• ENST00000285407
• ENSP00000285407
• ENSG00000155090
• ENST00000395884
• ENSP00000379222

Symbol

• TIEG
• TIEG1
• EGRA
• TIEG
• TIEG1
• EGR-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
transcription factor binding site profile	0.96
disease perturbation	0.93
biological process	0.9
small molecule perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Krueppel-like Factor 10

Protein / Transcription Factor / Transcription Cofactor / Krueppel-like Factor 10

Protein / Nucleic Acid Binding / Dna Binding Protein / Krueppel-like Factor 10

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Krueppel-like Factor 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.16   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 272   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.16   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0