Property Summary

NCBI Gene PubMed Count 40
PubMed Score 48.68
PubTator Score 26.00

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
ovarian cancer 8492 7.05429822162699E-7
sonic hedgehog group medulloblastoma 1482 6.17163489069407E-6
osteosarcoma 7933 1.82754937002049E-5
Pick disease 1893 2.25531542205882E-4
Waldenstrons macroglobulinemia 765 0.00198901303238213
primary pancreatic ductal adenocarcinoma 1271 0.00384193197326133
colon cancer 1475 0.0329928031679113

Expression

  Differential Expression (7)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.014 0.002
osteosarcoma -1.278 0.000
primary pancreatic ductal adenocarcinoma -1.088 0.004
colon cancer 2.800 0.033
sonic hedgehog group medulloblastoma 1.200 0.000
Pick disease -1.200 0.000
ovarian cancer -1.900 0.000

Synonym

Accession Q13042 A2A365 Q5T8C8 Q7Z651 Q96AE6 Q9Y564
Symbols APC6
CUT9
ANAPC6
CDC16Hs

Gene

PDB

4UI9   5A31   5G04   5G05   5KHR   5L9U   5LCW   3HYM  

  Ortholog (16)

Gene RIF (5)

PMID Text
20508983 Observational study of gene-disease association. (HuGE Navigator)
20056645 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19460752 Knockdown of cell division cycle 16 homolog (S. cerevisiae) (CDC16) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells
12629511 We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 which are known to be key function elements.
12029633 TFDP1, CUL4A, and CDC16 are probable targets of an amplification mechanism and therefore may be involved, together or separately, in development and/or progression of some hepatocellular carcinomas

AA Sequence

MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYE      1 - 70
ACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIY     71 - 140
DALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQELLRFLFENKLK    141 - 210
KYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNK    211 - 280
ANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEH    281 - 350
DQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT    351 - 420
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHS    421 - 490
LMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIIS    491 - 560
PPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETFEIEMNESDMMLETSMSDHST              561 - 620
//

Text Mined References (49)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
25416956 2014 A proteome-scale map of the human interactome network.
25043029 2014 Molecular architecture and mechanism of the anaphase-promoting complex.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21988832 2011 Toward an understanding of the protein interaction network of the human liver.
21926987 2011 APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
21269460 2011 Initial characterization of the human central proteome.
20508983 2011 Centrosome-related genes, genetic variation, and risk of breast cancer.
20360068 2010 Systematic analysis of human protein complexes identifies chromosome segregation proteins.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
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