Property Summary

NCBI Gene PubMed Count 32
Grant Count 9
Funding $1,196,742.18
PubMed Score 28.20
PubTator Score 45.02

Knowledge Summary

Patent (3,056)

Expression

  Differential Expression (8)

Disease log2 FC p
astrocytic glioma 1.200 0.045
ependymoma -2.000 0.000
group 4 medulloblastoma -2.700 0.000
atypical teratoid / rhabdoid tumor -1.600 0.020
medulloblastoma, large-cell -1.800 0.000
pilocytic astrocytoma 2.000 0.000
lung carcinoma 2.800 0.000
psoriasis -1.300 0.000

Gene RIF (29)

PMID Text
24449200 1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
23006490 Analyses revealed that polymorphism Ser310Ala of GRIK3 gene is not associated with alcohol dependence or any of its subgroups.
22232963 Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse
20859245 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20052609 Some support (at a nominal significance level of 0.05/0.01) was found for association between GRIK3 and depression.
19995671 Observational study of gene-disease association. (HuGE Navigator)
19921975 Our study suggests a potential role for GRIK3 for susceptibility to schizophrenia in Indian population.
19921975 Observational study of gene-disease association. (HuGE Navigator)
19320626 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRN      1 - 70
RTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHH     71 - 140
PLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPID    141 - 210
SDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLT    211 - 280
GFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQC    281 - 350
HRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA    351 - 420
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGK    421 - 490
YGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNP    491 - 560
LSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMP    561 - 630
KALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSK    631 - 700
ISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTP    701 - 770
MGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV    771 - 840
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMAC    841 - 910
STSLAPVFP                                                                 911 - 919
//

Text Mined References (34)

PMID Year Title
24449200 2014 1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
23894747 2013 A comprehensive family-based replication study of schizophrenia genes.
23006490 2013 Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence.
22232963 [Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome].
20859245 2011 Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20052609 2010 Association of existing and new candidate genes for anxiety, depression and personality traits in older people.
19995671 2010 Are GRIK3 (T928G) gene variants in schizophrenia patients different from those in their first-degree relatives?
19921975 2009 Association between the ionotropic glutamate receptor kainate3 (GRIK3) Ser310Ala polymorphism and schizophrenia in the Indian population.
19342380 2009 Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.
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