Property Summary

NCBI Gene PubMed Count 85
Grant Count 65
R01 Count 15
Funding $8,683,735.51
PubMed Score 265.60
PubTator Score 198.67

Knowledge Summary

Patent (72,362)

Expression

  Differential Expression (15)

Disease log2 FC p
malignant mesothelioma -2.400 0.000
astrocytic glioma 1.800 0.009
oligodendroglioma 2.400 0.021
osteosarcoma 1.908 0.027
posterior fossa group A ependymoma -2.800 0.000
glioblastoma -2.200 0.001
group 4 medulloblastoma -2.600 0.000
atypical teratoid / rhabdoid tumor -2.500 0.000
medulloblastoma, large-cell 2.800 0.000
lung cancer 3.700 0.000
pediatric high grade glioma -1.500 0.005
non primary Sjogren syndrome sicca -1.400 0.020
subependymal giant cell astrocytoma -2.955 0.047
lung carcinoma 3.500 0.000
ovarian cancer -1.500 0.000

Synonym

Accession Q13002 A6NMY9 B5MCV0 D7RWZ3 D7RWZ4 D7RWZ5 D7RWZ6 D7RWZ7 Q8WWS1 Q96KS6 Q96KS7 Q96KS8 GluK2
Symbols EAA4
GLR6
MRT6
GLUK6
GLUR6
GluK2

Gene

PDB

3QXM   5CMM  

  TechDev Info (1)

Susumu Tomita Examining potential modulators

 GWAS Trait (1)

Gene RIF (53)

PMID Text
27324535 In the Han population in Central China, the polymorphisms of SNP rs9390754 in the GRIK2 gene may be associated with epilepsy susceptibility.
26277340 Study demonstrates that co-assembly of recombinant kainate receptors (GluK1 and GluK2) with the Neto1 and Neto2 auxiliary subunits alters their onset and recovery from desensitization in a subunit-dependent manner
25842862 High risk genetic markers of paranoid schizophrenia were GRIK2*ATG and GRIK2*TGG in Tatars.
25316086 Parkin interacts with the kainate receptor GluK2 subunit and regulates KAR function.
25201974 The present study reveals an additional mechanism for the regulation of GluK2-containing kainate receptors by Src family kinases, which may be of pathological significance in ischemic stroke.
24821223 This study showed that Gluk2 association with obsessive-compulsive disorder.
24662927 This study found in GRIK2 (glutamate receptor, ionotropic kainate 2) was most significant and also showed significant correlations with gene expression.
23861400 14-3-3 proteins are an important regulator of GluK2a-containing KARs and may contribute to the slow decay kinetics of native KAR-EPSCs.
23713029 Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state.
23660601 we found no association between rs1556995 in GRIK2 and clozapine-induced obsessive-compulsive (OC) symptoms, implying that that GRIK2 may not play a role in the development of OC symptoms in schizophrenia patients
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AA Sequence

MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTL      1 - 70
LPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSD     71 - 140
NKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKD    141 - 210
AKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFR    211 - 280
ILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRH    281 - 350
KPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK    351 - 420
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGA    421 - 490
QDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLS    491 - 560
PDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKA    561 - 630
LSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKIS    631 - 700
TYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPM    701 - 770
GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG    771 - 840
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA      841 - 908
//

Text Mined References (89)

PMID Year Title
27324535 2016 [Association between glutamate receptor 2 polymorphisms and epilepsy in children].
26277340 2015 The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.
25842862 [Glutamate receptors genes polymorphism and the risk of paranoid schizophrenia in Russians and tatars from the Republic of Bashkortostan].
25316086 2014 Parkin regulates kainate receptors by interacting with the GluK2 subunit.
25201974 2014 Tyrosine phosphorylation of GluK2 up-regulates kainate receptor-mediated responses and downstream signaling after brain ischemia.
25199915 2015 GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.
24821223 2015 Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
24662927 2015 Astrocytic abnormalities and global DNA methylation patterns in depression and suicide.
23861400 2013 Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins.
23713029 2013 Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state.
More...