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Tbio
RALGDS
Ral guanine nucleotide dissociation stimulator

Protein Summary
Description
Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372047
  • ENSP00000361117
  • ENSG00000160271
  • ENST00000372050
  • ENSP00000361120
  • ENST00000372062
  • ENSP00000361132
  • ENST00000393157
  • ENSP00000376864
  • ENST00000393160
  • ENSP00000376867

Symbol
  • KIAA1308
  • RGF
  • RGF
  • RGDS
  • RalGEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.86
transcription factor perturbation
0.74
transcription factor
0.72
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.55   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.55   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0