Property Summary

NCBI Gene PubMed Count 158
Grant Count 215
R01 Count 135
Funding $19,227,846.12
PubMed Score 165.05
PubTator Score 193.34

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (18)

Synonym

Accession Q12959 A5YKK7 B4DGU1 B4DGZ8 B7ZMM0 B9EIQ5 D3DXB8 D3DXB9 E7EWL7 E9PG21 Q12958
Symbols hdlg
DLGH1
SAP97
SAP-97
dJ1061C18.1.1

Gene

PDB

3LRA   3RL7   3RL8   4G69   1PDR   2M3M   2OQS   2X7Z   3W9Y   4AMH  

Gene RIF (92)

PMID Text
26653181 Human papillomavirus oncoproteins E6 and E7 induce the loss of DLG1 from the cell borders and an increase in the level of DLG1 protein, reflecting the pattern observed in cervical lesions.
26440542 Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified.
25720117 The study provides new evidence for understanding the transcriptional regulation of DLG1 and the changes in DLG1 expression during different biological processes.
25499266 While other domains of SAP97 were involved in forward trafficking of GluN1-3 out of the endoplasmic reticulum (ER), the SH3 domain was necessary and sufficient to block the ER retention.
25429624 the synapse-associated protein-97 (SAP97), an excitatory synapse scaffolding element, governs ADAM10 trafficking from dendritic Golgi outposts to synaptic membranes, mediated by a previously uncharacterized protein kinase C.
25275262 DLG1, XIST, DDX3Y and RPS4Y1 genes can classify samples into different group clearly, and they are regarded as high confidence distinct gene biomarkers of Parkinson disease.
25268382 Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg.
25253337 These findings indicate that most, if not all, human adenovirus E4-ORF1 proteins share a conserved molecular mechanism of PI3K activation via Dlg1 binding and confer a common capacity to promote oncogenic transformation.
24989932 SAP97 plays a conserved role in regulating 5-HT2AR endocytosis and ERK1/2 signaling, but plays a novel role in regulating 5-HT2AR G protein coupling.
24937328 Novel genetic variants in the coding regions of DLG1 gene associated with susceptibility to Crohn's disease.
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AA Sequence

MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRS      1 - 70
KPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEK     71 - 140
NLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETP    141 - 210
TYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN    211 - 280
EVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYV    281 - 350
TKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT    351 - 420
NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIF    421 - 490
ISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDL    491 - 560
REQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVT    561 - 630
PDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYV    631 - 700
LSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQME    701 - 770
KDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME    771 - 840
MNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL          841 - 904
//

Text Mined References (178)

PMID Year Title
26653181 2016 Disc large 1 expression is altered by human papillomavirus E6/E7 proteins in organotypic cultures of human keratinocytes.
26440542 2015 Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25720117 2015 Transcriptional and translational mechanisms contribute to regulate the expression of Discs Large 1 protein during different biological processes.
25558062 2015 GPR124 functions as a WNT7-specific coactivator of canonical ?-catenin signaling.
25499266 2015 SAP97 blocks the RXR ER retention signal of NMDA receptor subunit GluN1-3 through its SH3 domain.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25447080 2015 Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current.
25429624 2014 SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation.
25275262 2014 Identifying distinct candidate genes for early Parkinson's disease by analysis of gene expression in whole blood.
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