Property Summary

NCBI Gene PubMed Count 89
Grant Count 58
R01 Count 36
Funding $7,392,137.09
PubMed Score 177.87
PubTator Score 162.58

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
malignant mesothelioma -2.000 0.000
glioblastoma multiforme 1.200 0.000
cystic fibrosis 2.052 0.000
intraductal papillary-mucinous adenoma (... -1.200 0.004
intraductal papillary-mucinous carcinoma... -1.400 0.004
lung cancer -2.400 0.000
active Crohn's disease 1.662 0.003
active ulcerative colitis 1.231 0.022
interstitial cystitis -1.700 0.000
lung adenocarcinoma -1.200 0.000
group 4 medulloblastoma -2.100 0.001
lung carcinoma -3.400 0.000
spina bifida -2.061 0.038
ovarian cancer -2.900 0.000

Synonym

Accession Q12923 B2RTR0 Q15159 Q15263 Q15264 Q15265 Q15674 Q16826 Q8IWH7 Q9NYN9 Q9UDA8
Symbols PNP1
FAP-1
PTP1E
PTPL1
PTPLE
PTP-BL
hPTP1E
PTP-BAS

Gene

PDB

1D5G   1Q7X   1WCH   2M0Z   2M10   3LNX   3LNY   3PDZ  

Gene RIF (55)

PMID Text
25933631 This work studied heat diffusion in the well-known PDZ-2 protein, and confirmed that this protein has two cognate allosteric pathways and that heat flows preferentially through these.
25893857 Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13
25494785 The effect of the viscogens sucrose, and glycerol on the kinetic response of a photoperturbed PTPN13 is investigated.
25448478 A PDZ-mediated interaction of PTPN13 and PTEN is described with possible relevance for tumor suppression.
25365469 A comprehensive molecular dynamics simulation study of the PDZ2 domain of human tyrosine phosphatase 1E in the ligand-bound and -free state, as well as the photoswitchable protein in the cis and trans states of the photoswitch
24338422 Association of rs7014346 in POU5F1P1, rs989902 in PTPN13, and rs7003146 in TCF7L2 with variations in the risk of breast cancer in a Chinese Han population.
24316673 selective autophagic degradation of the phosphatase Fap-1 promotes Fas apoptosis.
24191246 Thus, our results suggest a previously unknown Stat3-PTPN13 molecular network controlling squamous cell lung carcinoma development
23950995 HCV induced increased expression of miR200c can down modulate the expression of FAP1, a critical regulator of Src and MAP kinase pathway that play an important role in the production of fibrogenic growth factors and development of fibrosis.
23906871 Low PTPN13 expression is associated with invasion and metastasis of lung squamous cell carcinoma.
More...

AA Sequence

MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDEN      1 - 70
ISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVI     71 - 140
YARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLP    141 - 210
TGRSSTSDVLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTS    211 - 280
GPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIA    281 - 350
LDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS    351 - 420
IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQL    421 - 490
QAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSI    491 - 560
LTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDL    561 - 630
KLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSL    631 - 700
LLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVC    701 - 770
QRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD    771 - 840
GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTG    841 - 910
SLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYP    911 - 980
HRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPG    981 - 1050
QAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLG   1051 - 1120
IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPV   1121 - 1190
HLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQ   1191 - 1260
VNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSS   1261 - 1330
SQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAV   1331 - 1400
IPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLS   1401 - 1470
DQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQ   1471 - 1540
PAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQV   1541 - 1610
LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALH   1611 - 1680
QTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSM   1681 - 1750
DKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQD   1751 - 1820
PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNK   1821 - 1890
EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVL   1891 - 1960
KATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIK   1961 - 2030
GSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTE   2031 - 2100
DTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDH   2101 - 2170
SFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRK   2171 - 2240
NRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQ   2241 - 2310
EVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHD   2311 - 2380
TPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGM   2381 - 2450
VQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK                                      2451 - 2485
//

Text Mined References (94)

PMID Year Title
25933631 2015 Allosteric communication pathways and thermal rectification in PDZ-2 protein: a computational study.
25893857 2015 The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.
25494785 2014 Effect of viscogens on the kinetic response of a photoperturbed allosteric protein.
25448478 2015 PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.
25365469 2014 Long-range conformational transition of a photoswitchable allosteric protein: molecular dynamics simulation study.
24338422 2013 Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population.
24316673 2014 Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
24191246 2013 Stat3 inhibits PTPN13 expression in squamous cell lung carcinoma through recruitment of HDAC5.
24159190 2014 Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
23950995 2013 Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis.
More...