Tclin SLC10A2 Ileal sodium/bile acid cotransporter

Protein Summary

Description

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q12908
• A1L4F4
• Q13839

Gene Name

• SLC10A2

Ensembl ID

• ENST00000245312
• ENSP00000245312
• ENSG00000125255

Symbol

• ASBT
• ISBT
• NTCP2
• ASBT
• IBAT
• ISBT
• PBAM
• NTCP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
gene perturbation	0.85
microRNA	0.65
disease	0.6
cell line	0.56

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Ileal Sodium/bile Acid Cotransporter

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc10 Family Of Sodium-bile Acid Co-transporters / Ileal Sodium/bile Acid Cotransporter

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.34   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.34   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 199

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3