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Tbio
TRIM26
Tripartite motif-containing protein 26

Protein Summary
Description
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327357
  • ENSP00000331131
  • ENSG00000137313
  • ENST00000383607
  • ENSP00000373102
  • ENST00000396558
  • ENSP00000379806
  • ENST00000415923
  • ENSP00000415755
  • ENSG00000231002
  • ENST00000422349
  • ENSP00000396188
  • ENSG00000234046
  • ENST00000425523
  • ENSP00000393011
  • ENSG00000228881
  • ENST00000425831
  • ENSP00000394371
  • ENSG00000231641
  • ENST00000427535
  • ENSP00000398545
  • ENST00000428486
  • ENSP00000414248
  • ENST00000432326
  • ENSP00000407876
  • ENST00000433314
  • ENSP00000402395
  • ENSG00000226060
  • ENST00000436219
  • ENSP00000390258
  • ENSG00000230230
  • ENST00000437089
  • ENSP00000395491
  • ENSG00000234127
  • ENST00000438384
  • ENSP00000416737
  • ENST00000438908
  • ENSP00000409182
  • ENST00000439094
  • ENSP00000389203
  • ENST00000445259
  • ENSP00000407294
  • ENST00000447711
  • ENSP00000408233
  • ENST00000450392
  • ENSP00000394421
  • ENST00000453195
  • ENSP00000391879
  • ENST00000454678
  • ENSP00000410446
  • ENST00000455000
  • ENSP00000392805
  • ENST00000456093
  • ENSP00000406707
  • ENST00000456770
  • ENSP00000415328

Symbol
  • RNF95
  • ZNF173
  • AFP
  • RNF95
  • ZNF173
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
protein domain
0.97
kinase perturbation
0.84
phenotype
0.71
tissue sample
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.55   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.55   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0