Property Summary

NCBI Gene PubMed Count 96
PubMed Score 189.23
PubTator Score 261.86

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count
IGA Glomerulonephritis 454
Disease Target Count
Diabetes mellitus type 2 69
Disease Target Count P-value
non-small cell lung cancer 2798 2.36325794884215E-15
lung adenocarcinoma 2714 1.50761844424974E-12
Duchenne muscular dystrophy 602 2.19992296969407E-10
malignant mesothelioma 3163 4.94498049380315E-10
posterior fossa group B ependymoma 1530 3.15193685124673E-7
cystic fibrosis 1670 1.06522507628345E-6
interstitial cystitis 2299 6.35966194472675E-6
breast carcinoma 1614 3.83930162174212E-4
pancreatic cancer 2300 8.25491399662676E-4
primary pancreatic ductal adenocarcinoma 1271 9.89250176793221E-4
sonic hedgehog group medulloblastoma 1482 0.00310928248077641
adrenocortical carcinoma 1427 0.00367347278413469
osteosarcoma 7933 0.00691350871094269
ulcerative colitis 2087 0.0117207284122106
ovarian cancer 8492 0.018348751770553
Breast cancer 3099 0.0226493960636325
lung cancer 4473 0.0237464865958941
invasive ductal carcinoma 2950 0.0322195079152462
gastric carcinoma 832 0.0358304994502719
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0384053831985857
Disease Target Count Z-score Confidence
Crohn's disease 304 0.0 2.0
Vitiligo 71 0.0 2.0
Disease Target Count Z-score Confidence
diabetes mellitus 1663 4.457 2.2
Pharyngitis 17 3.211 1.6
Hypoglycemia 81 3.045 1.5

Expression

Synonym

Accession Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4
Symbols FAPA
SIMP
DPPIV
FAPalpha

Gene

FAP

PDB

1Z68  

  Ortholog (15)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG
Fruitfly EggNOG Inparanoid
S.cerevisiae OMA EggNOG

 MGI Term (1)

Gene RIF (80)

PMID Text
27020681 Data suggest that a DNA vaccine targeting human fibroblast activation protein alpha (FAPalpha) may be an attractive and effective cancer immunotherapy strategy.
26962859 Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
26934296 FAP selectively cleaves type I collagen resulting in increased macrophage adhesion.
26797127 This study identified fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21.
26635356 the circulating protease, fibroblast activation protein, is the proteolytic enzyme responsible for hFGF21 inactivation.
26621486 NPY is efficiently cleaved by FAP indicating a potential function for FAP in neuropeptide regulation within liver and cancer biology.
26454160 FAP is expressed by activated, collagen-synthesizing fibroblasts, but not by inactive fibroblasts or fully differentiated myofibroblasts and non-fibroblast cells in the infarct.
26342814 FAP sensitizes fibrosarcoma to chemotherapy and alters cell death.
26319660 In this study, we show for the first time the expression of FAP in activated fibroblasts after MI and its activation by TGFbeta1. Effects of FAP on fibroblast migration and gelatinolytic activity indicate a potential role in cardiac wound healing
26304112 degradomic study highlights cell-contextual proteolysis by FAPalpha with distinct positional profiles. Generally, our findings link FAPalpha to key aspects of CAF biology and attribute an important role in tumor-stroma interaction to FAPalpha
More...

AA Sequence

MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQ      1 - 70
SADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEF     71 - 140
VRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKY    141 - 210
ALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEV    211 - 280
PVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGF    281 - 350
FVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPG    351 - 420
RRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEE    421 - 490
NKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISY    491 - 560
LASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVS    561 - 630
SLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGT    631 - 700
ADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD              701 - 760
//

Text Mined References (107)

PMID Year Title
27020681 2016 Anti-tumor effects of DNA vaccine targeting human fibroblast activation protein ? by producing specific immune responses and altering tumor microenvironment in the 4T1 murine breast cancer model.
26962859 2016 Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
26934296 2016 Cleavage of Type I Collagen by Fibroblast Activation Protein-? Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion.
26797127 2016 Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
26635356 2016 Circulating FGF21 proteolytic processing mediated by fibroblast activation protein.
26621486 2016 Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma.
26454160 2015 Has the search for a marker of activated fibroblasts finally come to an end?
26342814 2015 Integral membrane protease fibroblast activation protein sensitizes fibrosarcoma to chemotherapy and alters cell death mechanisms.
26319660 2015 Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction.
26304112 2016 Fibroblast activation protein-?, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations.
More...