Tbio CHD3 Chromodomain-helicase-DNA-binding protein 3

Protein Summary

Description

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q12873
• D3DTQ9
• E9PG89
• Q9Y4I0
• CHD-3

Gene Name

• CHD3

Ensembl ID

• ENST00000330494
• ENSP00000332628
• ENSG00000170004
• ENST00000358181
• ENSP00000350907
• ENST00000380358
• ENSP00000369716

Symbol

• ZFH
• Mi-2a
• SNIBCPS
• Mi2-ALPHA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	1
interacting protein	0.99
hub protein	0.97
co-expressed gene	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.19   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 263   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.19   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0