SFSWAP
Splicing factor, suppressor of white-apricot homolog
Protein Summary
Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]
- ENST00000261674
- ENSP00000261674
- ENSG00000061936
- ENST00000541286
- ENSP00000437738
- SFRS8
- SWAP
- SWAP
- SFRS8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.95 | ||
histone modification site profile | 0.93 | ||
virus perturbation | 0.92 | ||
transcription factor binding site profile | 0.87 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.27 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 170 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.27 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 170 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0