Tchem MAP3K12 Mitogen-activated protein kinase kinase kinase 12

Protein Summary

Description

Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q12852
• B3KSS9
• G3V1Y2
• Q86VQ5
• Q8WY25

Gene Name

• MAP3K12

Ensembl ID

• ENST00000267079
• ENSP00000267079
• ENSG00000139625
• ENST00000547035
• ENSP00000448689
• ENST00000547488
• ENSP00000449038

Symbol

• ZPK
• DLK
• MUK
• ZPK
• ZPKP1
• MEKK12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
kinase perturbation	0.95
disease perturbation	0.87
protein domain	0.85
transcription factor binding site profile	0.83

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Mlk Family / Mitogen-activated Protein Kinase Kinase Kinase 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.91   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.91   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 389

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0