Tbio STX4 Syntaxin-4

Protein Summary

Description

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

Uniprot Accession IDs

• Q12846
• A8MXY0
• Q15525
• Q6FHE8

Gene Name

• STX4

Ensembl ID

• ENST00000313843
• ENSP00000317714
• ENSG00000103496
• ENST00000394998
• ENSP00000378447

Symbol

• STX4A
• STX4A
• p35-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
biological process	0.96
disease perturbation	0.95
histone modification site profile	0.93
protein complex	0.87

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-4

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.71   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.71   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0