Property Summary

NCBI Gene PubMed Count 40
PubMed Score 93.87
PubTator Score 50.14

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
glioblastoma multiforme 347 6.16639237551077E-23
lung carcinoma 2844 7.52078751603989E-15
posterior fossa group B ependymoma 1530 7.97410492992881E-12
juvenile dermatomyositis 1189 2.80574865028895E-9
Duchenne muscular dystrophy 602 1.21374119569669E-7
sonic hedgehog group medulloblastoma 1482 2.08716609187023E-6
ovarian cancer 8492 2.87942247453317E-6
ulcerative colitis 2087 3.8211531838292E-6
limb girdle muscular dystrophy 2A 156 3.38267342205282E-5
atypical teratoid / rhabdoid tumor 4369 3.56221236178347E-5
breast carcinoma 1614 2.10261356179925E-4
primary pancreatic ductal adenocarcinoma 1271 2.50534576755475E-4
fascioscapulohumeral muscular dystrophy 100 2.95441319835085E-4
adrenocortical carcinoma 1427 3.43119544477918E-4
pancreatic cancer 2300 3.88659038256117E-4
pancreatic carcinoma 567 7.06206432546278E-4
invasive ductal carcinoma 2950 8.98908384048928E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00142070331468811
adult high grade glioma 2148 0.00143445716925137
osteosarcoma 7933 0.00197153334691195
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00355966688872984
medulloblastoma, large-cell 6234 0.00394029520507642
gastric carcinoma 832 0.00613424846904358
Becker muscular dystrophy 187 0.00729583579294325
primitive neuroectodermal tumor 3031 0.00793348275248839
ductal carcinoma in situ 1745 0.00921314785352749
Atopic dermatitis 944 0.0149487096191254
subependymal giant cell astrocytoma 2287 0.0176522638526385
chronic kidney disease 90 0.0336206347438122
X-linked recessive Emery-Dreifuss muscular dystrophy 18 0.0425878195001312
Disease Target Count Z-score Confidence
Arthritis 248 3.068 1.5



Accession Q12841 A8K523 B4DTT5 D3DN90 Q549Z0
Symbols FRP


PANTHER Protein Class (1)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (26)

26903060 Children with chronic heart failure group had a significantly higher serum level of FSTL1 than the control group.
26375005 data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardial infarction in humans
26365350 provide mechanistic insight into the regulation of erythropoiesis by FSTL1 signaling and lay a foundation for exploring FSTL1 signaling as a therapeutic target for anemia
26355153 administration of Fstl1 induced airway remodeling and increased OSM, whereas administration of an anti-OSM Ab blocked the effect of Fstl1 on inducing airway remodeling, eosinophilic airway inflammation
25888873 FSTL1 is elevated in patients with osteoarthritis and involved in the progression of synovial inflammation.
25584011 Fstl1 is induced in response to lung injury and promotes the accumulation of myofibroblasts and subsequent fibrosis. These data suggest that Fstl1 may serve as a novel therapeutic target for treatment of progressive lung fibrosis.
24838142 FSTL1 is elevated in various inflammatory conditions and decreased during the course of treatment. FSTL1 may therefore be a valuable biomarker for such diseases.
24470197 These results suggest that FSTL-1 may act on the NLRP3 inflammasome to promote IL-1beta secretion from monocytes/macrophages.
24347831 FSTL1 is a potential mediator of inflammation and insulin resistance in obesity.
23419164 results demonstrated that follistatin-like protein 1 (Fstl1) is expressed and secreted by human myotubes and plasma Fstl1 levels are increased after exercise

AA Sequence

EEMTRYVQELQKHQETAEKTKRVSTKEI                                              281 - 308

Text Mined References (44)

PMID Year Title
26903060 2016 [Change in serum follistatin-like protein 1 and its clinical significance in children with chronic heart failure].
26375005 2015 Epicardial FSTL1 reconstitution regenerates the adult mammalian heart.
26365350 2015 Follistatin-like 1 attenuates differentiation and survival of erythroid cells through Smad2/3 signaling.
26355153 2015 Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M.
26091039 2015 A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
25888873 2015 The involvement of follistatin-like protein 1 in osteoarthritis by elevating NF-?B-mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation.
25584011 2015 Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice.
25416956 2014 A proteome-scale map of the human interactome network.
24838142 2014 Follistatin-like protein 1 and its role in inflammation and inflammatory diseases.
24470197 2014 Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1? secretion from monocytes and macrophages.