Tclin KCNH2 Potassium voltage-gated channel subfamily H member 2

Protein Summary

Description

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661). Isoform A-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. Isoform B-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q12809
• A5H1P7
• C4PFH9
• D3DX04
• O75418
• O75680
• Q708S9
• Q9BT72
• Q9BUT7
• Q9H3P0

Gene Name

• KCNH2

Ensembl ID

• ENST00000262186
• ENSP00000262186
• ENSG00000055118
• ENST00000330883
• ENSP00000328531

Symbol

• ERG
• ERG1
• HERG
• ERG1
• HERG
• LQT2
• SQT1
• ERG-1
• H-ERG
• HERG1
• Kv11.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
molecular function	1
protein domain	1
drug	0.91
hub protein	0.9

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / H (Eag) Subfamily / Kv11.1/kcnh2 Sub-subfamily / Potassium Voltage-gated Channel Subfamily H Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2924.25   (req: < 5)

Gene RIFs: 556   (req: <= 3)

Antibodies: 325   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2924.25   (req: >= 5)

Gene RIFs: 556   (req: > 3)

Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6062

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 109