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Tbio
HYAL1
Hyaluronidase-1

Protein Summary
Description
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266031
  • ENSP00000266031
  • ENSG00000114378
  • ENST00000320295
  • ENSP00000346068
  • ENST00000395143
  • ENSP00000378575
  • ENST00000395144
  • ENSP00000378576
  • ENST00000447605
  • ENSP00000390149
  • ENST00000457214
  • ENSP00000393358
  • ENST00000618175
  • ENSP00000477903

Symbol
  • LUCA1
  • MPS9
  • NAT6
  • LUCA1
  • HYAL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
cellular component
0.72
tissue sample
0.7
molecular function
0.63
pathway
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0