Tclin KCNMA1 Calcium-activated potassium channel subunit alpha-1

Protein Summary

Description

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q12791
• F8WA96
• Q12886
• Q12917
• Q12921
• Q12960
• Q13150
• Q5JQ23
• Q5SQR9
• Q96LG8
• Q9UBB0
• Q9UCX0
• Q9UQK6

Gene Name

• KCNMA1

Ensembl ID

• ENST00000286627
• ENSP00000286627
• ENSG00000156113
• ENST00000286628
• ENSP00000286628
• ENST00000434208
• ENSP00000402150
• ENST00000480683
• ENSP00000474686
• ENST00000626620
• ENSP00000485867
• ENST00000638575
• ENSP00000492049
• ENST00000638759
• ENSP00000492632
• ENST00000640969
• ENSP00000492200

Symbol

• KCNMA
• SLO
• SLO
• BKTM
• SLO1
• hSlo
• MaxiK
• PNKD3
• SAKCA
• mSLO1
• CADEDS
• KCa1.1
• SLO-ALPHA
• bA205K10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
molecular function	0.96
PubMedID	0.86
biological term	0.82
disease	0.79

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Calcium-activated Subfamily / Kca1.1/kcnma1 Sub-subfamily / Calcium-activated Potassium Channel Subunit Alpha-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1341.18   (req: < 5)

Gene RIFs: 167   (req: <= 3)

Antibodies: 302   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1341.18   (req: >= 5)

Gene RIFs: 167   (req: > 3)

Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2