| Tbio | Nuclear pore complex protein Nup160 |
Involved in poly(A)+ RNA transport.
NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]
NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| glioblastoma | 5572 | 1.43117542465607E-10 |
| osteosarcoma | 7933 | 3.64954796898483E-8 |
| atypical teratoid / rhabdoid tumor | 4369 | 1.23827342188612E-7 |
| primitive neuroectodermal tumor | 3031 | 6.48791569504464E-7 |
| pediatric high grade glioma | 2712 | 1.31318262101754E-6 |
| sonic hedgehog group medulloblastoma | 1482 | 3.64211822617774E-6 |
| pilocytic astrocytoma | 3086 | 7.16406073214316E-6 |
| medulloblastoma, large-cell | 6234 | 3.67410418431553E-5 |
| psoriasis | 6685 | 1.46631765328077E-4 |
| lung cancer | 4473 | 5.19623902920368E-4 |
| oligodendroglioma | 2849 | 0.00372536244335564 |
| ependymoma | 2514 | 0.00611461860942802 |
| ovarian cancer | 8492 | 0.00633663090310122 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.0228648859911099 |
| aldosterone-producing adenoma | 664 | 0.0306424710333896 |
| astrocytic glioma | 2241 | 0.0422426597034661 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Vascular cancer | 3 | 3.013 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.700 | 0.042 |
| ependymoma | 2.500 | 0.006 |
| oligodendroglioma | 2.300 | 0.004 |
| psoriasis | -1.700 | 0.000 |
| glioblastoma | 2.100 | 0.000 |
| osteosarcoma | -2.205 | 0.000 |
| sonic hedgehog group medulloblastoma | 2.400 | 0.000 |
| atypical teratoid / rhabdoid tumor | 2.300 | 0.000 |
| medulloblastoma, large-cell | 2.500 | 0.000 |
| primitive neuroectodermal tumor | 2.700 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | 1.100 | 0.023 |
| lung cancer | 1.500 | 0.001 |
| pediatric high grade glioma | 2.000 | 0.000 |
| pilocytic astrocytoma | 1.700 | 0.000 |
| aldosterone-producing adenoma | -1.030 | 0.031 |
| ovarian cancer | -1.200 | 0.006 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| Fruitfly | EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 26527604 | transcriptome sequencing of patient-derived angiosarcoma cells, identified a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined. |
| 25904327 | Nup107-160 complex and its partner Elys dynamically colocalize with Nup98 and CRM1 into endogenous GLFG bodies present in specific HeLa sublines. |
| 22031293 | The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. |
| 20974814 | The interactions of Nup160 with Pom121 and are predicted to assist in the formation of the nuclear pore and the anchoring of the Nuclear pore complexes to the pore membrane. |
| 20081840 | Data show that Nup107-160 promotes spindle assembly through Ran-GTP-regulated nucleation of microtubules by gamma-TuRC at kinetochores, and reveal a relationship between nucleoporins and the microtubule cytoskeleton. |
| 19864462 | A major function of the Nup107 complex in mitosis is to ensure the proper localization of the chromosome passenger complex at the centromere. |
| 19576787 | Data show that structure-guided sequence comparison of Nup160 and Saccharomyces cerevisiae Nup120 strongly suggests that both proteins adopt the same unique fold despite a low sequence identity of 10%. |
| 18187620 | Knockdown of nucleoporin 160kDa (NUP160) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells |
| 17363900 | These data thus provide the first molecular clues underlying the function of the human Nup107-160 complex at kinetochores. |
| 17360435 | phosphorylation does not affect interactions within the Nup107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins |
| More... |
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTA 1 - 70 NAVAGAVKYSESAGGFYYVESGKLFSVTRNRFIHWKTSGDTLELMEESLDINLLNNAIRLKFQNCSVLPG 71 - 140 GVYVSETQNRVIILMLTNQTVHRLLLPHPSRMYRSELVVDSQMQSIFTDIGKVDFTDPCNYQLIPAVPGI 141 - 210 SPNSTASTAWLSSDGEALFALPCASGGIFVLKLPPYDIPGMVSVVELKQSSVMQRLLTGWMPTAIRGDQS 211 - 280 PSDRPLSLAVHCVEHDAFIFALCQDHKLRMWSYKEQMCLMVADMLEYVPVKKDLRLTAGTGHKLRLAYSP 281 - 350 TMGLYLGIYMHAPKRGQFCIFQLVSTESNRYSLDHISSLFTSQETLIDFALTSTDIWALWHDAENQTVVK 351 - 420 YINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFCRGTERNLDLS 421 - 490 WSELKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQEALSHPLALHLNPHTNMVCLL 491 - 560 KKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISDDVDIARDVICLIKCLRLIEESVTVDMSVIMEMSCY 561 - 630 NLQSPEKAAEQILEDMITIDVENVMEDICSKLQEIRNPIHAIGLLIREMDYETEVEMEKGFNPAQPLNIR 631 - 700 MNLTQLYGSNTAGYIVCRGVHKIASTRFLICRDLLILQQLLMRLGDAVIWGTGQLFQAQQDLLHRTAPLL 701 - 770 LSYYLIKWGSECLATDVPLDTLESNLQHLSVLELTDSGALMANRFVSSPQTIVELFFQEVARKHIISHLF 771 - 840 SQPKAPLSQTGLNWPEMITAITSYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCR 841 - 910 FMLGRCYLVTGEGQKALECFCQAASEVGKEEFLDRLIRSEDGEIVSTPRLQYYDKVLRLLDVIGLPELVI 911 - 980 QLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEALTQIPDSSRQLDCLRQLVVVLCERSQLQDL 981 - 1050 VEFPYVNLHNEVVGIIESRARAVDLMTHNYYELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEK 1051 - 1120 QGNCYLAALNCLRLIRPEYAWIVQPVSGAVYDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKECSLA 1121 - 1190 RIRLTLAQHDPSAVAVAGSSSAEEMVTLLVQAGLFDTAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAA 1191 - 1260 QAEAWAWLAANQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVPLPNWLINSYK 1261 - 1330 KVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAPMVWLPYSSIDQLLQALGENS 1331 - 1400 ANSHNIALSQKILDKLEDYQQKVDKATRDLLYRRTL 1401 - 1436 //
| PMID | Year | Title |
|---|---|---|
| 26527604 | 2015 | NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma. |
| 25904327 | 2015 | Intranuclear dynamics of the Nup107-160 complex. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25173106 | 2014 | Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22031293 | 2011 | The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 20974814 | 2010 | Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane. |
| More... |
