Tbio CGNL1 Cingulin-like protein 1

Protein Summary

Description

May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q0VF96
• Q05BZ4
• Q52LR0
• Q695C7
• Q7Z2L3
• Q96JV2
• Q96MN6
• Q9C0B4

Gene Name

• CGNL1

Ensembl ID

• ENST00000281282
• ENSP00000281282
• ENSG00000128849

Symbol

• JACOP
• KIAA1749
• JACOP
• PCING

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.71
histone modification site profile	0.69
cell type or tissue	0.64
microRNA	0.64
transcription factor perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.69   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.69   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0