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Tbio
RASGEF1B
Ras-GEF domain-containing family member 1B

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264400
  • ENSP00000264400
  • ENSG00000138670
  • ENST00000335927
  • ENSP00000338437
  • ENST00000509081
  • ENSP00000425393

Symbol
  • GPIG4
  • GPIG4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
histone modification site profile
0.69
tissue sample
0.67
transcription factor binding site profile
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.65   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.65   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0