PDE4D
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Protein Summary
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
- ENST00000309641
- ENSP00000308485
- ENSG00000113448
- ENST00000317118
- ENSP00000321739
- ENST00000340635
- ENSP00000345502
- ENST00000358923
- ENSP00000351800
- ENST00000360047
- ENSP00000353152
- ENST00000405755
- ENSP00000384806
- ENST00000502484
- ENSP00000423094
- ENST00000502575
- ENSP00000425917
- ENST00000503258
- ENSP00000425605
- ENST00000507116
- ENSP00000424852
- DPDE3
- DPDE3
- PDE43
- STRK1
- ACRDYS2
- HSPDE4D
- PDE4DN2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
trait | 1 | ||
molecular function | 0.99 | ||
co-expressed gene | 0.96 | ||
microRNA | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 313.91 (req: < 5)
Gene RIFs: 153 (req: <= 3)
Antibodies: 427 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 313.91 (req: >= 5)
Gene RIFs: 153 (req: > 3)
Antibodies: 427 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 38
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 659
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7