Tchem DDR1 Epithelial discoidin domain-containing receptor 1

Protein Summary

Description

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q08345
• B5A975
• B5A976
• B7Z2K0
• Q14196
• Q16562
• Q2L6H3
• Q4LE50
• Q5ST11
• Q5ST12
• Q6NSK4
• Q9UD35
• Q9UD36
• Q9UD37
• Q9UD86
• Q9UDL2
• Epithelial discoidin domain receptor 1

Gene Name

• DDR1

Ensembl ID

• ENST00000259875
• ENSP00000259875
• ENSG00000137332
• ENST00000324771
• ENSP00000318217
• ENSG00000204580
• ENST00000376567
• ENSP00000365751
• ENST00000376568
• ENSP00000365752
• ENST00000376569
• ENSP00000365753
• ENST00000376570
• ENSP00000365754
• ENST00000376575
• ENSP00000365759
• ENST00000383377
• ENSP00000372868
• ENST00000400410
• ENSP00000383261
• ENST00000400411
• ENSP00000383262
• ENST00000400414
• ENSP00000383265
• ENST00000400486
• ENSP00000383334
• ENSG00000215522
• ENST00000400488
• ENSP00000383336
• ENST00000400489
• ENSP00000383337
• ENST00000400491
• ENSP00000383338
• ENST00000400492
• ENSP00000383339
• ENST00000412329
• ENSP00000391805
• ENSG00000230456
• ENST00000415092
• ENSP00000405540
• ENST00000418800
• ENSP00000407699
• ENST00000419412
• ENSP00000416183
• ENSG00000234078
• ENST00000421229
• ENSP00000415730
• ENST00000427053
• ENSP00000416145
• ENST00000429699
• ENSP00000401397
• ENST00000430933
• ENSP00000397769
• ENST00000449518
• ENSP00000414285
• ENST00000452441
• ENSP00000405039
• ENST00000453510
• ENSP00000401208
• ENST00000454612
• ENSP00000406091
• ENST00000454774
• ENSP00000400393
• ENST00000482873
• ENSP00000421978
• ENST00000508312
• ENSP00000422442
• ENST00000513240
• ENSP00000427552
• ENST00000548133
• ENSP00000449611
• ENST00000548962
• ENSP00000448115
• ENST00000549026
• ENSP00000449238
• ENST00000550384
• ENSP00000447474
• ENST00000550395
• ENSP00000449255
• ENST00000552068
• ENSP00000449190
• ENST00000552721
• ENSP00000449307
• ENST00000553015
• ENSP00000448377
• ENST00000617572
• ENSP00000479195
• ENST00000618059
• ENSP00000479204
• ENST00000620318
• ENSP00000484588
• ENST00000621544
• ENSP00000484013

Symbol

• CAK
• EDDR1
• NEP
• NTRK4
• PTK3A
• RTK6
• TRKE
• CAK
• DDR
• NEP
• HGK2
• PTK3
• RTK6
• TRKE
• CD167
• EDDR1
• MCK10
• NTRK4
• PTK3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.99
transcription factor perturbation	0.96
disease perturbation	0.93
PubMedID	0.93

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Ddr Family / Epithelial Discoidin Domain-containing Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.43   (req: < 5)

Gene RIFs: 158   (req: <= 3)

Antibodies: 706   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.43   (req: >= 5)

Gene RIFs: 158   (req: > 3)

Antibodies: 706   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 100

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10