| Tbio | Regulator of G-protein signaling 1 |
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 43 |
| Grant Count | 17 |
| R01 Count | 14 |
| Funding | $1,112,772.09 |
| PubMed Score | 97.81 |
| PubTator Score | 54.80 |
| PMID | Text |
|---|---|
| 26222051 | RGS1 as a potential marker of CRC tissue quality |
| 25897806 | RGS1 suppresses CXCL12-mediated migration and AKT activation in cultured human plasmacytoma cells and plasmablasts. |
| 25782711 | Rgs1 has a role in leukocyte trafficking and vascular inflammation |
| 24162774 | HIV-1 gp120 upregulates the expression of regulator of G-protein signaling 1 (RGS1) in human B cells |
| 24130709 | RGS1 and TNFRSF1A polymorphisms tended to be associated with reduced attack severity in Multiple sclerosis. |
| 23898208 | HIV-1 gp120 upregulates the expression of regulator of G-protein signaling 1 (RGS1) in human B cells |
| 23464602 | RGS1 is largely upregulated, whereas RGS2 is downregulated in the majority of solid tumors, whereas RGS5 transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies |
| 23324853 | Markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that reduces the risk of anxiety and depressive disorders. |
| 21795595 | Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines |
| 20647273 | Observational study of gene-disease association. (HuGE Navigator) |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26222051 | 2015 | Identification and Validation of a Potential Marker of Tissue Quality Using Gene Expression Analysis of Human Colorectal Tissue. |
| 25897806 | 2015 | Regulator of G protein signaling 1 suppresses CXCL12-mediated migration and AKT activation in RPMI 8226 human plasmacytoma cells and plasmablasts. |
| 25782711 | 2015 | RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. |
| 24130709 | 2013 | Multiple sclerosis susceptibility genes: associations with relapse severity and recovery. |
| 23464602 | 2013 | RGS expression in cancer: oncomining the cancer microarray data. |
| 23324853 | 2013 | Genetic association between RGS1 and internalizing disorders. |
| 21833088 | 2011 | Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. |
| 21795595 | 2011 | Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential. |
| 20647273 | 2010 | Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
| More... |
