| Tbio | Regulator of G-protein signaling 1 |
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arsenic Poisoning | 62 | 0.0 | 0.0 |
| Dermatitis, Allergic Contact | 67 | 0.0 | 0.0 |
| Skin Diseases | 71 | 0.0 | 0.0 |
| osteosarcoma | 7950 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Depressive disorder | 409 |
| Dermatologic disorders | 93 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Celiac disease | 116 | 3.567 | 1.8 |
| Multiple Sclerosis | 540 | 3.281 | 1.6 |
| Essential Hypertension | 94 | 0.0 | 1.7 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Griscelli syndrome type 3 | 13 | 3.608 | 1.8 |
| immunodeficiency-centromeric instability-facial anomalies syndrome | 16 | 3.354 | 1.7 |
