Protein Summary
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
- ENST00000342628
- ENSP00000342307
- ENSG00000111206
- ENST00000359843
- ENSP00000352901
- ENST00000361953
- ENSP00000354492
- FKHL16
- HFH11
- MPP2
- WIN
- MPP2
- HFH11
- HNF-3
- INS-1
- MPP-2
- PIG29
- FKHL16
- FOXM1A
- FOXM1B
- FOXM1C
- HFH-11
- TRIDENT
- MPHOSPH2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.94 | ||
co-expressed gene | 0.91 | ||
transcription factor perturbation | 0.88 | ||
kinase | 0.8 | ||
histone modification site profile | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1443.88 (req: < 5)
Gene RIFs: 606 (req: <= 3)
Antibodies: 432 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1443.88 (req: >= 5)
Gene RIFs: 606 (req: > 3)
Antibodies: 432 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1