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Tchem
FOXM1
Forkhead box protein M1

Protein Summary
Description
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342628
  • ENSP00000342307
  • ENSG00000111206
  • ENST00000359843
  • ENSP00000352901
  • ENST00000361953
  • ENSP00000354492

Symbol
  • FKHL16
  • HFH11
  • MPP2
  • WIN
  • MPP2
  • HFH11
  • HNF-3
  • INS-1
  • MPP-2
  • PIG29
  • FKHL16
  • FOXM1A
  • FOXM1B
  • FOXM1C
  • HFH-11
  • TRIDENT
  • MPHOSPH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
co-expressed gene
0.91
transcription factor perturbation
0.88
kinase
0.8
histone modification site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1443.88   (req: < 5)
Gene RIFs: 593   (req: <= 3)
Antibodies: 432   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1443.88   (req: >= 5)
Gene RIFs: 593   (req: > 3)
Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1