Tchem CYP24A1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Protein Summary

Description

Has a role in maintaining calcium homeostasis. Catalyzes the adrenodoxin-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07973
• Q15807
• Q32ML3
• Q5I2W7
• 24-OHase

Gene Name

• CYP24A1

Ensembl ID

• ENST00000216862
• ENSP00000216862
• ENSG00000019186
• ENST00000395954
• ENSP00000379284
• ENST00000395955
• ENSP00000379285

Symbol

• CYP24
• CP24
• HCAI
• CYP24
• HCINF1
• P450-CC24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
biological term	0.81
pathway	0.81
PubMedID	0.78
disease	0.72

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / 1,25-dihydroxyvitamin D(3) 24-hydroxylase, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / 1,25-dihydroxyvitamin D(3) 24-hydroxylase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1211.03   (req: < 5)

Gene RIFs: 217   (req: <= 3)

Antibodies: 296   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1211.03   (req: >= 5)

Gene RIFs: 217   (req: > 3)

Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1