| Tchem | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 43 |
| NCBI Gene PubMed Count | 168 |
| PubMed Score | 825.91 |
| PubTator Score | 416.68 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypercalcemia | 59 | 5.159 | 2.6 |
| Abortion, Spontaneous | 109 | 0.0 | 0.0 |
| Breast Neoplasms | 445 | 0.0 | 0.0 |
| Hypercalcemia, Infantile | 3 | 0.0 | 0.0 |
| Hypercalciuria | 27 | 0.0 | 0.0 |
| Lung Neoplasms | 232 | 0.0 | 0.0 |
| Nephrolithiasis | 56 | 0.0 | 0.0 |
| Osteoporosis | 363 | 0.0 | 0.0 |
| Renal Insufficiency | 90 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 3.5e-148 |
| periodontitis | 293 | 1.5e-28 |
| cystic fibrosis | 1696 | 4.3e-07 |
| malignant mesothelioma | 3232 | 6.3e-06 |
| non-small cell lung cancer | 2890 | 1.2e-05 |
| lung adenocarcinoma | 2716 | 7.9e-05 |
| lung cancer | 4740 | 5.2e-04 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Atopic dermatitis | 952 | 0.0 | 3.0 |
| Multiple Sclerosis | 540 | 0.0 | 3.0 |
| Disease | Target Count |
|---|---|
| Autosomal recessive infantile hypercalcemia | 2 |
| Disease | log2 FC | p |
|---|---|---|
| cystic fibrosis | -3.553 | 4.3e-07 |
| lung adenocarcinoma | 1.700 | 7.9e-05 |
| lung cancer | 1.700 | 5.2e-04 |
| malignant mesothelioma | -2.900 | 6.3e-06 |
| non-small cell lung cancer | 1.292 | 1.2e-05 |
| periodontitis | 1.400 | 1.5e-28 |
| psoriasis | 3.500 | 3.5e-148 |
CHEMBL363039
pIC50 6.05
CHEMBL3344401
pKi 6.13
CHEMBL3344399
pKi 6.14
CHEMBL3344403
pKi 6.19
CHEMBL3329779
pIC50 6.22
CHEMBL1627205
pIC50 6.26
CHEMBL3344402
pKi 6.27
CHEMBL3344397
pIC50 6.28
CHEMBL3344396
pIC50 6.28
CHEMBL3329771
pIC50 6.29
CHEMBL3344393
pIC50 6.36
CHEMBL3329775
pKi 6.40
CHEMBL1171494
pIC50 6.40
CHEMBL3329776
pKi 6.42
CHEMBL3344392
pIC50 6.44
CHEMBL3329768
pIC50 6.47
CHEMBL3344398
pKi 6.47
CHEMBL3329767
pIC50 6.59
CHEMBL3344400
pKi 6.64
CHEMBL3329777
pKi 6.68
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSL 1 - 70 LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDY 71 - 140 RKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKW 141 - 210 SFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFK 211 - 280 SVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQ 281 - 350 KLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ 351 - 420 VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN 421 - 490 EPVEMLHSGTLVPSRELPIAFCQR 491 - 514 //
