Tchem BCL2L1 Bcl-2-like protein 1

Protein Summary

Description

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q07817
• E1P5L6
• Q5CZ89
• Q5TE65
• Q92976
• Bcl2-L-1

Gene Name

• BCL2L1

Ensembl ID

• ENST00000307677
• ENSP00000302564
• ENSG00000171552
• ENST00000376055
• ENSP00000365223
• ENST00000376062
• ENSP00000365230

Symbol

• BCL2L
• BCLX
• BCLX
• BCL2L
• Bcl-X
• PPP1R52
• BCL-XL/S

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
transcription factor perturbation	1
biological process	0.99
kinase perturbation	0.99
protein domain	0.99

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Bcl-2-like Protein 1

DTO Classes

Protein / Signaling / Bcl-2-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4313.36   (req: < 5)

Gene RIFs: 522   (req: <= 3)

Antibodies: 1812   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4313.36   (req: >= 5)

Gene RIFs: 522   (req: > 3)

Antibodies: 1812   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 781

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2