Tbio SCN1B Sodium channel subunit beta-1

Protein Summary

Description

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Isoform 2: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth. Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q07699
• Q5TZZ4
• Q6TN97

Gene Name

• SCN1B

Ensembl ID

• ENST00000262631
• ENSP00000262631
• ENSG00000105711
• ENST00000415950
• ENSP00000396915
• ENST00000638536
• ENSP00000492022

Symbol

• ATFB13
• BRGDA5
• EIEE52
• GEFSP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
small molecule perturbation	0.83
disease perturbation	0.79
biological process	0.77
histone modification site profile	0.65

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Sodium Channel Subunit Beta-1

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Sodium Channel Subunit Beta-1

DTO Classes

Protein / Ion Channel / Sodium Channel Auxiliary Subunit 1-4 (Sca-) Family / Scn1b Family / Sodium Channel Subunit Beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.43   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.43   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0