Tbio SPAG1 Sperm-associated antigen 1

Protein Summary

Description

May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07617
• A6NP70
• B3KQ58
• G3XAM3
• Q7Z5G1

Gene Name

• SPAG1

Ensembl ID

• ENST00000251809
• ENSP00000251809
• ENSG00000104450
• ENST00000388798
• ENSP00000373450
• ENST00000520508
• ENSP00000428070
• ENST00000520643
• ENSP00000427716

Symbol

• SP75
• TPIS
• CT140
• CILD28
• HSD-3.8
• HEL-S-268

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
protein domain	0.73
tissue sample	0.69
gene perturbation	0.66
cell line	0.55

Protein Classes

DTO Classes

Sperm-associated Antigen 16 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.31   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.31   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0