Property Summary

NCBI Gene PubMed Count 24
PubMed Score 50.72
PubTator Score 25.50

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
osteosarcoma 7933 2.94777927193685E-6
ovarian cancer 8492 5.95010417822294E-6
sonic hedgehog group medulloblastoma 1482 8.76316492948184E-6
acute quadriplegic myopathy 1157 4.90342289095531E-5
psoriasis 6685 2.69512061178658E-4
diabetes mellitus 1663 0.00135732104365388
Multiple myeloma 1328 0.00493659192150355
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00619359724052884
colon cancer 1475 0.0160561702018671
Waldenstrons macroglobulinemia 765 0.01734474496388
lung cancer 4473 0.0412317256324854
Disease Target Count Z-score Confidence
Esotropia 13 3.058 1.5

Expression

  Differential Expression (11)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.377 0.017
Multiple myeloma 1.573 0.005
psoriasis 1.200 0.000
osteosarcoma 1.332 0.000
acute quadriplegic myopathy 1.029 0.000
intraductal papillary-mucinous neoplasm ... -1.200 0.006
colon cancer 1.500 0.016
lung cancer -3.000 0.041
diabetes mellitus -1.900 0.001
sonic hedgehog group medulloblastoma 1.100 0.000
ovarian cancer -1.500 0.000

Synonym

Accession Q07020 F8VWC5 Q8WTZ6
Symbols L18

Gene

PDB

4UG0   4V6X   5AJ0  

  Ortholog (14)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
Zebrafish OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
S.cerevisiae EggNOG Inparanoid

Gene RIF (5)

PMID Text
26092250 Silencing of the RPL-18 does not affect cell translation efficiency or viability, but it reduces significantly viral translation, replication and viral yield, suggesting that the RPL-18 is required during the Dengue virus replicative cycle.
23125841 Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L18 (RPL18), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
18854154 Knockdown of ribosomal protein L18 (RPL18) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1

AA Sequence

MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKM      1 - 70
KLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLS     71 - 140
GPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN                          141 - 188
//

Text Mined References (34)

PMID Year Title
26092250 2015 Dengue virus NS1 protein interacts with the ribosomal protein RPL18: this interaction is required for viral translation and replication in Huh-7 cells.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24941225 2014 Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23636399 2013 Structures of the human and Drosophila 80S ribosome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21926972 2011 Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
21630459 2011 Proteomic characterization of the human sperm nucleus.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
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